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Oxford University Press, Nucleic Acids Research, D1(45), p. D190-D199, 2016

DOI: 10.1093/nar/gkw1107

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InterPro in 2017-beyond protein family and domain annotations

Journal article published in 2016 by Rd Finn, Teresa K. Attwood, Sc Tosatto ORCID, Patricia C. Babbitt, Ch Wu, Alex Bateman ORCID, Peer Bork, Ls Yeh, Sy Young, Zsuzsanna Dosztányi, Sara El-Gebali ORCID, Matthew Fraser, Julian Gough, David Haft, Aj Bridge and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

InterPro (http://www.ebi.ac.uk/interpro/) is a freely available database used to classify protein sequences into families and to predict the presence of important domains and sites. InterProScan is the underlying software that allows both protein and nucleic acid sequences to be searched against InterPro's predictive models, which are provided by its member databases. Here, we report recent developments with InterPro and its associated software, including the addition of two new databases (SFLD and CDD), and the functionality to include residue-level annotation and prediction of intrinsic disorder. These developments enrich the annotations provided by InterPro, increase the overall number of residues annotated and allow more specific functional inferences.