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IOS Press, Journal of Alzheimer's Disease, 3(60), p. 809-817, 2017

DOI: 10.3233/jad-160645

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Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease

Journal article published in 2016 by Min Nevado-Holgado A. Whiley L. Snowden S. G. Soininen H. Kloszewska I. Mecocci P. Tsolaki M. Vellas B. Thambisetty M. Dobson R. J. Powell J. F. Lupton M. K. Simmons A. Velayudhan L. Lovestone S. Proitsi P. Legido-Quigley C. Kim, Alejo Nevado-Holgado, Luke Whiley, Stuart G. Snowden, Hilkka Soininen, Iwona Kloszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Madhav Thambisetty, Richard J. B. Dobson ORCID, John F. Powell, Michelle K. Lupton, Andy Simmons, Latha Velayudhan ORCID and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Lipids such as ceramides (Cer) and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer's disease (AD) patients in a number of discovery studies. For this reason, the levels of 6 ceramides and 3 PCs, with different fatty acid length and saturation levels, were measured in the plasma from 412 participants (AD n = 205, Control n = 207) using mass spectrometry coupled with ultra-performance liquid chromatography. After this, associations with AD status, brain atrophy, and age-related effects were studied. In the plasma of AD participants, cross-sectional analysis revealed elevated levels of three ceramides (Cer16:0 p 75, p