MOESM5 of The cancer-associated CTCFL/BORIS protein targets multiple classes of genomic repeats, with a distinct binding and functional preference for humanoid-specific SVA transposable elements
Published in 2016 by
Elena Pugacheva,
Evgeny Teplyakov,
Qiongfang Wu,
Jingjing Li,
Cheng Chen,
Chengcheng Meng,
Jian Liu,
Susan Robinson,
Dmitry Loukinov,
Abdelhalim Boukaba,
Andrew Hutchins,
Victor Lobanenkov,
Alexander Strunnikov
Abstract
Additional file 5: Figure S3. The expression of SVA elements that are transcribed in K562 cells is not affected by BORIS dosage. RNA-seq differential ratio distribution for 75 SVA elements, which were apparently transcriptionally active in the untreated K562 cells (i.e., over 10 normalized counts in empty vector control). Only elements longer than 1Â Kb were included in analysis. Shown are the graphs for BORIS KD K562 cells, K562 treated with DZNep and the combination of both treatments.