Additional file 9: of Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay
Published in 2016 by
Maria Pia Abruzzese,
Maria Bilotta,
Cinzia Fionda,
Alessandra Zingoni,
Alessandra Soriani,
Elisabetta Vulpis,
Cristiana Borrelli,
Beatrice Zitti,
Maria Petrucci,
Maria Ricciardi,
Rosa Molfetta,
Rossella Paolini,
Angela Santoni,
Marco Cippitelli
Abstract
shRNA interference of BRD4 upregulates MICA expression in SKO-007(J3) cells. (A) MICA, MICB, and PVR/CD155 cell surface expression were analyzed by flow cytometry on pLKO-control (non-targeting) or pLKO-BRD4-lentivirus-infected SKO-007(J3) cells (72 h). The MFI of MICA, MICB, and PVR/CD155 was calculated based on three independent experiments and evaluated by paired Student t test (*P