DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

Ligthart, Symen; Whi Empc, Investigators; Tanaka, Toshiko; Marzi, Carola; Smith, Jennifer A. (Jennifer A); Aslibekyan, Stella; Waite, Lindsay L.; Mendelson, Michael M. (Michael M.); Conneely, Karen N. (Karen N.); Colicino, Elena; Joehanes, Roby; Ward-Caviness, Cavin K. (Cavin K.); Guan, Weihua; Brody, Jennifer A.; Elks, Cathy E. (Cathy); Marioni, Riccardo E. (Riccardo); Wahl, Simone; Jhun, Min A. (Min A.); Agha, Golareh; Bressler, Jan; Chen, Brian H. (Brian); Sotoodehnia, Nona; Huan, Tianxiao; Bakulski, Kelly M. (Kelly M.); Salfati, Elias L.; Tsao, Phil S. (Phil S.); Fiorito, Giovanni; Zhao, Wei; Schramm, Katharina; Sha, Jin; Hernandez, Dena G. (Dena); Just, Allan C. (Allan C.); Vokonas, Pantel; Pilling, Luke C. (Luke); Pankow, James S. (James); van Meurs, Joyce B. J.; Liu, Chunyu; Yao, Chen; Guarrera, Simonetta; Michopoulos, Vasiliki J. (Vasiliki J.); Charge, epigenetics of Coronary Heart Disease; Smith, Alicia K. (Alicia K.); Peters, Marjolein J. (Marjolein); Melzer, David; Wareham, Nicholas J. (Nick); Smith, Jennifer A.; Fornage, Myriam; Wiggins, Kerri L. (Kerri); Prokisch, Holger; Bis, Joshua C. (Joshua); Starr, John M. (John); Chu, Audrey Y. (Audrey); Visscher, Peter M.; Herder, Christian; Grallert, Harald; Shah, Sonia; McRae, Allan F. (Allan F.); Lin, Honghuang; Horvath, Steve; Waldenberger, Melanie; Fallin, Daniele; Hofman, Albert; Uitterlinden, André G. (André); Feinberg, Andrew P. (Andrew P.); Murabito, Joanne M.; Kardia, Sharon L. R. (Sharon L. R.); Absher, Devin M.; Turner, Stephen T. (Stephen); Binder, Elisabeth B. (Elisabeth); Singleton, Andrew B.; Bandinelli, Stefania; Peters, Annette; Matullo, Giuseppe; Schwartz, Joel D. (Joel D.); Demerath, Ellen W. (Ellen); Franco, Oscar H. (Oscar); Meurs, Jbj B. J. (Joyce B. J.); Chen, Yii-Der Ida; Levy, Daniel; Deary, Ian J. (Ian J.); Ressler, Kerry J. (Kerry); Dupuis, Josée; Ferrucci, Luigi; Ong, Ken K. (Ken K.); Assimes, Themistocles L. (Themistocles); Boerwinkle, Eric A. (Eric); Koenig, Wolfgang; Arnett, Donna K. (Donna); Baccarelli, Andrea A. (Andrea A.); Benjamin, Emelia J. (Emelia); Dehghan, Abbas

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DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

Journal article published in 2016 by Symen Ligthart, Investigators Whi Empc, Toshiko Tanaka, Carola Marzi, Jennifer A. (Jennifer A) Smith, Stella Aslibekyan, Lindsay L. Waite, Michael M. (Michael M.) Mendelson, Karen N. (Karen N.) Conneely, Elena Colicino, Roby Joehanes, Cavin K. (Cavin K.) Ward-Caviness, Weihua Guan, Jennifer A. Brody, Cathy E. (Cathy) Elks and other authors.

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Abstract

Abstract Background Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation. Results We performed a meta-analysis of epigenome-wide association studies (EWAS) of serum C-reactive protein (CRP), which is a sensitive marker of low-grade inflammation, in a large European population (n = 8863) and trans-ethnic replication in African Americans (n = 4111). We found differential methylation at 218 CpG sites to be associated with CRP (P

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DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

Abstract