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Nature Research, Nature Genetics, 6(41), p. 648-650, 2009

DOI: 10.1038/ng.386

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Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

Journal article published in 2009 by John R. B. Perry, Lisette Stolk, Nora Franceschini, Kathryn L. Lunetta ORCID, Guangju Zhai, Patrick F. McArdle, Albert V. Smith ORCID, Thor Aspelund, Stefania Bandinelli, Eric Boerwinkle, Lynn Cherkas, Gudny Eiriksdottir, Karol Estrada, Luigi Ferrucci, Aaron R. Folsom and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.