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BioMed Central, Genome Biology, 10(10), p. R112

DOI: 10.1186/gb-2009-10-10-r112

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Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels

Journal article published in 2009 by Ian Sudbery, Jim Stalker, Jared T. Simpson, Thomas Keane, Alistair G. Rust, Matthew E. Hurles, Klaudia Walter ORCID, Dee Lynch, Lydia Teboul ORCID, Steve D. Brown, Heng Li, Zemin Ning, Joseph H. Nadeau, Colleen M. Croniger, Richard Durbin ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Genome sequences are essential tools for comparative and mutational analyses. Here we present the short read sequence of mouse chromosome 17 from the Mus musculus domesticus derived strain A/J, and the Mus musculus castaneus derived strain CAST/Ei. We describe approaches for the accurate identification of nucleotide and structural variation in the genomes of vertebrate experimental organisms, and show how these techniques can be applied to help prioritize candidate genes within quantitative trait loci.