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Cardiac Alpha-V Beta-3 Integrin Expression Following Acute Myocardial Infarction in Humans

This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

Other ; This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by the British Medical Journal Publishing Group. ; Abstract ; $\textbf{Objective}$ Maladaptive repair contributes towards the development of heart failure following myocardial infarction (MI). The α$_{v}$β$_{3}$ integrin receptor is a key mediator and determinant of cardiac repair. We aimed to establish whether α$_{v}$β$_{3}$ integrin expression determines myocardial recovery following MI. $\textbf{Methods}$ 18F-Fluciclatide (a novel α$_{v}$β$_{3}$-selective radiotracer) positron emission tomography (PET) and computed tomography (CT) imaging, and gadolinium-enhanced magnetic resonance imaging (CMR) were performed in 21 patients 2 weeks after ST-segment elevation MI (anterior,n=16; lateral,n=4; inferior,n=1). Cardiac CMR was repeated 9 months after MI. Seven stable patients with chronic total occlusion (CTO) of a major coronary vessel, and 9 healthy volunteers underwent a single PET/CT and CMR. $\textbf{Results}$ 18F-Fluciclatide uptake was increased at sites of acute infarction compared to remote myocardium (tissue-to-background ratio (TBR$_{mean}$) 1.34±0.22 vs 0.85±0.17; p