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Detection of anti-drug antibodies using a bridging ELISA compared with radioimmunoassay in adalimumab-treated rheumatoid arthritis patients with random drug levels
Journal article published in 2016 by
John D. Isaacs,
Meghna Jani 
,
Ann W. Morgan,
Anthony G. Wilson,
Darren Plant,
Kimme L. Hyrich,
Hector Chinoy,
Anne Barton
,
Ann W. Morgan,
Anthony G. Wilson,
Darren Plant,
Kimme L. Hyrich,
Hector Chinoy,
Anne Barton
Abstract
Objective. To determine the concordance between RIA and bridging ELISA at detecting anti-drug antibodies (ADAbs) in the context of random adalimumab levels and investigate the additional clinical utility of detecting ADAbs in RA patients who test ADAb positive by RIA and negative by ELISA.