52 Genetic Loci Influencing Myocardial Mass

van der Harst, Pim; van Setten, Jessica; Verweij, Niek; Vogler, Georg; Franke, Lude; Maurano, Matthew T.; Wang, Xinchen; Mateo Leach, Irene; Eijgelsheim, Mark; Sotoodehnia, Nona; Hayward, Caroline; Sorice, Rossella; Meirelles, Osorio; Lyytikäinen, Leo-Pekka; Polašek, Ozren; Tanaka, Toshiko; Arking, Dan E.; Ulivi, Sheila; Trompet, Stella; Müller-Nurasyid, Martina; Smith, Albert V.; Dörr, Marcus; Kerr, Kathleen F.; Magnani, Jared W.; Del Greco M., Fabiola; Zhang, Weihua; Nolte, Ilja M.; Silva, Claudia T.; Padmanabhan, Sandosh; Tragante, Vinicius; Esko, Tõnu; Abecasis, Gonçalo R.; Adriaens, Michiel E.; Andersen, Karl; Barnett, Phil; Bis, Joshua C.; Bodmer, Rolf; Buckley, Brendan M.; Campbell, Harry; Cannon, Megan V.; Chakravarti, Aravinda; Chen, Lin Y.; Delitala, Alessandro; Devereux, Richard B.; Doevendans, Pieter A.; Dominiczak, Anna F.; Ferrucci, Luigi; Ford, Ian; Gieger, Christian; Harris, Tamara B.; Haugen, Eric; Heinig, Matthias; Hernandez, Dena G.; Hillege, Hans L.; Hirschhorn, Joel N.; Hofman, Albert; Hubner, Norbert; Hwang, Shih-Jen; Iorio, Annamaria; Kähönen, Mika; Kellis, Manolis; Kolcic, Ivana; Kooner, Ishminder K.; Kooner, Jaspal S.; Kors, Jan A.; Lakatta, Edward G.; Lage, Kasper; Launer, Lenore J.; Levy, Daniel; Lundby, Alicia; Macfarlane, Peter W.; May, Dalit; Meitinger, Thomas; Metspalu, Andres; Nappo, Stefania; Naitza, Silvia; Neph, Shane; Nord, Alex S.; Nutile, Teresa; Okin, Peter M.; Olsen, Jesper V.; Oostra, Ben A.; Penninger, Josef M.; Pennacchio, Len A.; Pers, Tune H.; Perz, Siegfried; Peters, Annette; Pinto, Yigal M.; Pfeufer, Arne; Pilia, Maria Grazia; Pramstaller, Peter P.; Prins, Bram P.; Raitakari, Olli T.; Raychaudhuri, Soumya; Rice, Ken M.; Rossin, Elizabeth J.; Rotter, Jerome I.; Schafer, Sebastian; Schlessinger, David; Schmidt, Carsten O.; Sehmi, Jobanpreet; Silljé, Herman H. W.; Sinagra, Gianfranco; Sinner, Moritz F.; Slowikowski, Kamil; Soliman, Elsayed Z.; Spector, Timothy D.; Spiering, Wilko; Stamatoyannopoulos, John A.; Stolk, Ronald P.; Strauch, Konstantin; Tan, Sian-Tsung; Tarasov, Kirill V.; Trinh, Bosco; Uitterlinden, Andre G.; van den Boogaard, Malou; van Duijn, Cornelia M.; van Gilst, Wiek H.; Viikari, Jorma S.; Visscher, Peter M.; Vitart, Veronique; Völker, Uwe; Waldenberger, Melanie; Weichenberger, Christian X.; Westra, Harm-Jan; Wijmenga, Cisca; Wolffenbuttel, Bruce H.; Yang, Jian; Bezzina, Connie R.; Munroe, Patricia B.; Snieder, Harold; Wright, Alan F.; Rudan, Igor; Boyer, Laurie A.; Asselbergs, Folkert W.; van Veldhuisen, Dirk J.; Stricker, Bruno H.; Psaty, Bruce M.; Ciullo, Marina; Sanna, Serena; Lehtimäki, Terho; Wilson, James F.; Bandinelli, Stefania; Alonso, Alvaro; Gasparini, Paolo; Jukema, J. Wouter; Kääb, Stefan; Gudnason, Vilmundur; Felix, Stephan B.; Heckbert, Susan R.; de Boer, Rudolf A.; Newton-Cheh, Christopher; Hicks, Andrew A.; Chambers, John C.; Jamshidi, Yalda; Visel, Axel; Christoffels, Vincent M.; Isaacs, Aaron; Samani, Nilesh J.; de Bakker, Paul I. W.

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Lin Chen
van der Harst et al., 2016

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Elsevier, Journal of the American College of Cardiology, 13(68), p. 1435-1448, 2016

DOI: 10.1016/j.jacc.2016.07.729

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@article{van der Harst2016,
  abstract = {BACKGROUND: Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death. OBJECTIVES: This meta-analysis sought to gain insights into the genetic determinants of myocardial mass. METHODS: We carried out a genome-wide association meta-analysis of 4 QRS traits in up to 73,518 individuals of European ancestry, followed by extensive biological and functional assessment. RESULTS: We identified 52 genomic loci, of which 32 are novel, that are reliably associated with 1 or more QRS phenotypes at p },
  author = {van der Harst, Pim and van Setten, Jessica and Verweij, Niek and Vogler, Georg and Franke, Lude and Maurano, Matthew T. and Wang, Xinchen and Mateo Leach, Irene and Eijgelsheim, Mark and Sotoodehnia, Nona and Hayward, Caroline and Sorice, Rossella and Meirelles, Osorio and Lyytikäinen, Leo-Pekka and Polašek, Ozren and Tanaka, Toshiko and Arking, Dan E. and Ulivi, Sheila and Trompet, Stella and Müller-Nurasyid, Martina and Smith, Albert V. and Dörr, Marcus and Kerr, Kathleen F. and Magnani, Jared W. and Del Greco M., Fabiola and Zhang, Weihua and Nolte, Ilja M. and Silva, Claudia T. and Padmanabhan, Sandosh and Tragante, Vinicius and Esko, Tõnu and Abecasis, Gonçalo R. and Adriaens, Michiel E. and Andersen, Karl and Barnett, Phil and Bis, Joshua C. and Bodmer, Rolf and Buckley, Brendan M. and Campbell, Harry and Cannon, Megan V. and Chakravarti, Aravinda and Chen, Lin Y. and Delitala, Alessandro and Devereux, Richard B. and Doevendans, Pieter A. and Dominiczak, Anna F. and Ferrucci, Luigi and Ford, Ian and Gieger, Christian and Harris, Tamara B. and Haugen, Eric and Heinig, Matthias and Hernandez, Dena G. and Hillege, Hans L. and Hirschhorn, Joel N. and Hofman, Albert and Hubner, Norbert and Hwang, Shih-Jen and Iorio, Annamaria and Kähönen, Mika and Kellis, Manolis and Kolcic, Ivana and Kooner, Ishminder K. and Kooner, Jaspal S. and Kors, Jan A. and Lakatta, Edward G. and Lage, Kasper and Launer, Lenore J. and Levy, Daniel and Lundby, Alicia and Macfarlane, Peter W. and May, Dalit and Meitinger, Thomas and Metspalu, Andres and Nappo, Stefania and Naitza, Silvia and Neph, Shane and Nord, Alex S. and Nutile, Teresa and Okin, Peter M. and Olsen, Jesper V. and Oostra, Ben A. and Penninger, Josef M. and Pennacchio, Len A. and Pers, Tune H. and Perz, Siegfried and Peters, Annette and Pinto, Yigal M. and Pfeufer, Arne and Pilia, Maria Grazia and Pramstaller, Peter P. and Prins, Bram P. and Raitakari, Olli T. and Raychaudhuri, Soumya and Rice, Ken M. and Rossin, Elizabeth J. and Rotter, Jerome I. and Schafer, Sebastian and Schlessinger, David and Schmidt, Carsten O. and Sehmi, Jobanpreet and Silljé, Herman H. W. and Sinagra, Gianfranco and Sinner, Moritz F. and Slowikowski, Kamil and Soliman, Elsayed Z. and Spector, Timothy D. and Spiering, Wilko and Stamatoyannopoulos, John A. and Stolk, Ronald P. and Strauch, Konstantin and Tan, Sian-Tsung and Tarasov, Kirill V. and Trinh, Bosco and Uitterlinden, Andre G. and van den Boogaard, Malou and van Duijn, Cornelia M. and van Gilst, Wiek H. and Viikari, Jorma S. and Visscher, Peter M. and Vitart, Veronique and Völker, Uwe and Waldenberger, Melanie and Weichenberger, Christian X. and Westra, Harm-Jan and Wijmenga, Cisca and Wolffenbuttel, Bruce H. and Yang, Jian and Bezzina, Connie R. and Munroe, Patricia B. and Snieder, Harold and Wright, Alan F. and Rudan, Igor and Boyer, Laurie A. and Asselbergs, Folkert W. and van Veldhuisen, Dirk J. and Stricker, Bruno H. and Psaty, Bruce M. and Ciullo, Marina and Sanna, Serena and Lehtimäki, Terho and Wilson, James F. and Bandinelli, Stefania and Alonso, Alvaro and Gasparini, Paolo and Jukema, J. Wouter and Kääb, Stefan and Gudnason, Vilmundur and Felix, Stephan B. and Heckbert, Susan R. and de Boer, Rudolf A. and Newton-Cheh, Christopher and Hicks, Andrew A. and Chambers, John C. and Jamshidi, Yalda and Visel, Axel and Christoffels, Vincent M. and Isaacs, Aaron and Samani, Nilesh J. and de Bakker, Paul I. W.},
  doi = {10.1016/j.jacc.2016.07.729},
  journal = {Journal of the American College of Cardiology},
  month = {sep},
  pages = {1435-1448},
  title = {52 Genetic Loci Influencing Myocardial Mass},
  url = {http://www.hirsla.lsh.is/lsh/bitstream/2336/620027/3/1-s2.0-S0735109716346605-main.pdf},
  volume = {68},
  year = {2016}
}

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52 Genetic Loci Influencing Myocardial Mass

Journal article published in 2016 by Pim van der Harst, Jessica van Setten, Niek Verweij, Georg Vogler, Lude Franke, Matthew T. Maurano, Xinchen Wang, Irene Mateo Leach, Mark Eijgelsheim, Nona Sotoodehnia, Caroline Hayward, Rossella Sorice, Osorio Meirelles, Leo-Pekka Lyytikäinen, Ozren Polašek and other authors. Pim van der Harst, Jessica van Setten, Niek Verweij, Georg Vogler, Lude Franke, Matthew T. Maurano, Xinchen Wang, Irene Mateo Leach, Mark Eijgelsheim, Nona Sotoodehnia, Caroline Hayward, Rossella Sorice, Osorio Meirelles, Leo-Pekka Lyytikäinen, Ozren Polašek, Toshiko Tanaka, Dan E. Arking, Sheila Ulivi, Stella Trompet, Martina Müller-Nurasyid, Albert V. Smith, Marcus Dörr, Kathleen F. Kerr, Jared W. Magnani, Fabiola Del Greco M., Weihua Zhang, Ilja M. Nolte, Claudia T. Silva, Sandosh Padmanabhan, Vinicius Tragante, Tõnu Esko, Gonçalo R. Abecasis, Michiel E. Adriaens, Karl Andersen, Phil Barnett, Joshua C. Bis, Rolf Bodmer, Brendan M. Buckley, Harry Campbell, Megan V. Cannon, Aravinda Chakravarti, Lin Y. Chen

, Alessandro Delitala, Richard B. Devereux, Pieter A. Doevendans, Anna F. Dominiczak, Luigi Ferrucci, Ian Ford, Christian Gieger, Tamara B. Harris, Eric Haugen, Matthias Heinig

, Dena G. Hernandez, Hans L. Hillege, Joel N. Hirschhorn, Albert Hofman, Norbert Hubner, Shih-Jen Hwang, Annamaria Iorio, Mika Kähönen, Manolis Kellis, Ivana Kolcic, Ishminder K. Kooner, Jaspal S. Kooner, Jan A. Kors, Edward G. Lakatta

, Kasper Lage, Lenore J. Launer, Daniel Levy, Alicia Lundby, Peter W. Macfarlane, Dalit May, Thomas Meitinger, Andres Metspalu, Stefania Nappo, Silvia Naitza, Shane Neph, Alex S. Nord

, Teresa Nutile, Peter M. Okin, Jesper V. Olsen, Ben A. Oostra, Josef M. Penninger, Len A. Pennacchio, Tune H. Pers, Siegfried Perz, Annette Peters, Yigal M. Pinto, Arne Pfeufer, Maria Grazia Pilia, Peter P. Pramstaller

, Bram P. Prins, Olli T. Raitakari, Soumya Raychaudhuri, Ken M. Rice, Elizabeth J. Rossin, Jerome I. Rotter, Sebastian Schafer

, David Schlessinger, Carsten O. Schmidt, Jobanpreet Sehmi, Herman H. W. Silljé, Gianfranco Sinagra

, Moritz F. Sinner, Kamil Slowikowski, Elsayed Z. Soliman, Timothy D. Spector, Wilko Spiering, John A. Stamatoyannopoulos, Ronald P. Stolk, Konstantin Strauch, Sian-Tsung Tan, Kirill V. Tarasov, Bosco Trinh, Andre G. Uitterlinden, Malou van den Boogaard, Cornelia M. van Duijn, Wiek H. van Gilst, Jorma S. Viikari, Peter M. Visscher, Veronique Vitart, Uwe Völker, Melanie Waldenberger, Christian X. Weichenberger, Harm-Jan Westra, Cisca Wijmenga, Bruce H. Wolffenbuttel, Jian Yang

, Connie R. Bezzina, Patricia B. Munroe, Harold Snieder, Alan F. Wright, Igor Rudan, Laurie A. Boyer, Folkert W. Asselbergs, Dirk J. van Veldhuisen, Bruno H. Stricker, Bruce M. Psaty, Marina Ciullo, Serena Sanna

, Terho Lehtimäki, James F. Wilson, Stefania Bandinelli, Alvaro Alonso, Paolo Gasparini, J. Wouter Jukema, Stefan Kääb, Vilmundur Gudnason, Stephan B. Felix, Susan R. Heckbert, Rudolf A. de Boer, Christopher Newton-Cheh, Andrew A. Hicks, John C. Chambers, Yalda Jamshidi, Axel Visel, Vincent M. Christoffels, Aaron Isaacs, Nilesh J. Samani, Paul I. W. de Bakker

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Abstract

BACKGROUND: Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death. OBJECTIVES: This meta-analysis sought to gain insights into the genetic determinants of myocardial mass. METHODS: We carried out a genome-wide association meta-analysis of 4 QRS traits in up to 73,518 individuals of European ancestry, followed by extensive biological and functional assessment. RESULTS: We identified 52 genomic loci, of which 32 are novel, that are reliably associated with 1 or more QRS phenotypes at p

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52 Genetic Loci Influencing Myocardial Mass

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