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Samara National Research University, Journal of Biomedical Photonics and Engineering, p. 020201-1-020201-16, 2016

DOI: 10.18287/jbpe16.02.020201

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Optical diffraction tomography techniques for the study of cell pathophysiology

Journal article published in 2016 by Kyoohyun Kim, Jonghee Yoon, Seungwoo Shin, SangYun Lee, Su-A. Yang, YongKeun Park
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Three-dimensional imaging of biological cells is crucial for the investigation of cell biology, providing valuable information to reveal the mechanisms behind pathophysiology of cells and tissues. Recent advances in optical diffraction tomography (ODT) have demonstrated the potential for the study of various cells with its unique advantages of quantitative and label-free imaging capability. To provide insight on this rapidly growing field of research and to discuss its applications in biology and medicine, we present the summary of the ODT principle and highlight recent studies utilizing ODT with the emphasis on the applications to the pathophysiology of cells.