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Taylor and Francis Group, Journal of Asian Natural Products Research, 5(19), p. 448-456, 2016

DOI: 10.1080/10286020.2016.1232714

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Isolation, structure elucidation, and induction of hepatoma cell apoptosis of abietane diterpenoids from Abies faxoniana

Journal article published in 2016 by Guo-Wei Wang, Chao Lv, Yun-Heng Shen, Wei-Dong Zhang
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Two new abietane diterpenoids ( 1 – 2 ) and 13 known compounds ( 3 – 15 ) were characterized from the branches and leaves of Abies faxoniana . The chemical structures of the new diterpenoids ( 1 – 2 ) were determined through the analysis of various 1D/2D NMR techniques. Compound 3 is 151,617-trinor-abietane diterpenoid conjugated with a three-membered epoxide ring. The isolated diterpenoids were tested for their cytotoxicities. Among them, compound 3 exhibited the strongest antiproliferative effect against human hepatoma cell SMMC7721 with an IC 50 value of 12.5 μM. To elucidate the preliminary mechanism responsible for compound 3 -induced inhibition of cell proliferation, we investigated the effects of compound 3 on apoptosis, cell cycle progression, and reactive oxygen species generation in SMMC7721 cells. The results showed that compound 3 induced cell apoptosis and excessive ROS production, but did not change the cell cycle distribution in SMMC7721 cells.