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Elsevier, Urology Case Reports, (7), p. 67-69, 2016

DOI: 10.1016/j.eucr.2016.04.010

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The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer

Journal article published in 2016 by Rosanne C.-V. Van der Roest ORCID, Petra J. van Houdt ORCID, Stijn Wtpj Heijmink, Jeroen de Jong, André M. Bergman, Wilbert Zwart, Uulke A. van der Heide, Henk G. van der Poel
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The effects of enzalutamide monotherapy on prostate tumor downsizing and multiparametric MRI are currently unknown. Here we present the first case in literature of a patient with high-grade prostate cancer who underwent 3 months of neoadjuvant enzalutamide, for which the effects on mpMRI and histology were determined. Tumor size reduction and downstaging were noted. Neoadjuvant enzalutamide resulted in an increase in ADC value on the DWI-MRI sequences. Histological changes were also observed.