This study was conducted to evaluate the possible protective effect of Ginkgo biloba (GB) against testicular damage and oxidative stress induced by acute or subchronic intoxication with cisplatin (CIS) in rats. Sixty male albino rats were classified into 6 equal groups (n = 10). Rats were treated orally with 150 mg kg b.wt. day G1 GB extract for 5 successive days before and 25 successive days after induction of toxicity by i.p. injection of CIS. Rats received CIS either acutely as a single injection of CIS (24 mg kg –1 b.wt.) or sub chronically with four equal doses of CIS (6 mg kg –1 b.wt.) once weekly. After 72 h from the last CIS injection, pathological and oxidative testicular toxicity as well as serum testosterone level and sperm indices were evaluated. Rats exposed to subchronic CIS treatment (alone or with prior GB co-treatment) displayed a significant decrease (p