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Elsevier, Neuroscience & Biobehavioral Reviews, 8(32), p. 1533-1543

DOI: 10.1016/j.neubiorev.2008.06.005

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The Cyclic AMP Phenotype of Fragile X and Autism

Journal article published in 2008 by Daniel J. Kelley, Anita Bhattacharyya, Garet P. Lahvis, Jerry Cp Yin, Jim Malter, Richard J. Davidson ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism.