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Instituto de Medicina Tropical, Revista do Instituto de Medicina Tropical de São Paulo, 5(55), p. 323-328, 2013

DOI: 10.1590/s0036-46652013000500005

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Establishing the Reference Range for T Lymphocytes Subpopulations in Adults and Children From Brazil

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Data provided by SHERPA/RoMEO

Abstract

Os valores de refer?ncias de linf?citos T existentes no Brasil s?o baseados em dados originados de outros pa?ses. N?o existem dados locais da varia??o normal para estes par?metros em adultos e crian?as brasileiras. Avaliamos a varia??o normal encontrada em doadores de sangue de cinco grandes cidades brasileiras em diferentes regi?es e em crian?as residentes em Salvador e Rio de Janeiro. Todas as amostras foram processadas por citometria de fluxo. Os resultados foram analisados de acordo com regi?o, g?nero e estilo de vida dos doadores. Um total de 641 adultos (63% homens) e 280 crian?as (58% meninos) participaram do estudo. Valores absolutos de CD3+ e CD4+ foram significantemente maiores no g?nero feminino (adultos e crian?as). Maiores valores de CD4+ em adultos foram associados com tabagismo, enquanto que maiores valores de CD8+ foram encontrados entre crian?as do sexo feminino. Adultos das regi?es sul e sudeste apresentaram maiores valores absolutos para todas as c?lulas T enquanto que adultos da regi?o norte, apresentaram menores valores. Indiv?duos residentes no nordeste e centro-oeste obtiveram contagens intermedi?rias para todas as popula??es de c?lulas T. Entretanto, estas diferen?as entre as regi?es, n?o demonstraram diferen?a estat?stica. No Brasil, g?nero e tabagismo foram os principais determinantes para diferen?as em valores de refer?ncias de linf?citos T. ; ABSTRACT: In Brazil, the existing reference values for T-lymphocytes subsets are based on data originated in other countries. There is no local information on normal variation for these parameters in Brazilian adults and children. We evaluated the normal variation found in blood donors from five large Brazilian cities, in different regions, and in children living in Salvador, and Rio de Janeiro. All samples were processed by flow cytometry. The results were analyzed according to region, gender, and lifestyle of blood donors. A total of 641 adults (63% males), and 280 children (58% males) were involved in the study. The absolute CD3+, and CD4+ cells count were significantly higher for females (adults and children). Higher CD4+ cell count in adults was associated with smoking, while higher CD8+ count was found among female children. Higher counts, for all T-cells subsets, were detected in blood donors from southeast / south regions while those living in the northern region had the lowest values. Individuals from midwestern and northeastern regions had an intermediate count for all these cells subsets. However, these differences did not reach statistical significance. In Brazil, gender and smoking, were the main determinants of differences in T-lymphocytes reference values.