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BioMed Central, Diagnostic Pathology, 1(11), 2016

DOI: 10.1186/s13000-016-0485-3

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Limited independent prognostic value of MMP-14 and MMP-2 expression in ovarian cancer

This paper is available in a repository.
This paper is available in a repository.

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Abstract

Abstract Background In cancer, various MMPs play a role in progression and metastasis and their overexpression generally indicates a poor prognosis. MMP-14 is the main activator of MMP-2 and both molecules play a role in normal ovarian follicular development. Earlier reports indicated a prognostic value for both MMP-14 and MMP-2 in ovarian cancer. This study was designed to determine the prognostic value of MMP-14 and MMP-2 expression in ovarian cancer with data on long-term follow-up. Methods Tumor samples of 94 consecutive ovarian cancer patients from one regional laboratory were evaluated. Clinical and survival data were collected and related to known prognostic factors, as well as to the expression of MMP-14 and MMP-2 as determined by semi-quantitative immunohistochemistry. Results Epithelial MMP-14 expression correlated with stromal MMP-14 expression (rho = .47, p