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American Society of Hematology, Blood, 17(120), p. 3488-3490, 2012

DOI: 10.1182/blood-2012-07-445593

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HTLV-1–infected T cells contain a single integrated provirus in natural infection

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractHuman T lymphotropic virus type 1 (HTLV-1) appears to persist in the chronic phase of infection by driving oligoclonal proliferation of infected T cells. Our recent high-throughput sequencing study revealed a large number (often > 104) of distinct proviral integration sites of HTLV-1 in each host that is greatly in excess of previous estimates. Here we use the highly sensitive, quantitative high-throughput sequencing protocol to show that circulating HTLV-1+ clones in natural infection each contain a single integrated proviral copy. We conclude that a typical host possesses a large number of distinct HTLV-1–infected T-cell clones.