For the terminal phase of tactical missiles intercepting maneuvering targets, the terminal guidance problem is studied. Based on an integral sliding mode (ISM) control method and nonlinear disturbance observer technique, a novel composite guidance law is designed in the case of constrained impact angle and a first-order-lag autopilot. Regarding the target acceleration and the external disturbance of autopilot as unknown bounded disturbance, a nonlinear ISM guidance law is designed. The obtained guidance law guarantees the line-of-sight (LOS) angular rate and LOS angle a finite-time convergence characteristics. Then, to alleviate the chattering problem and guarantee the disturbance rejection performance, the composite guidance law combining the ISM guidance law with feedforward compensation terms based on nonlinear disturbance observers is obtained. Finally, simulation comparison results are provided to demonstrate the effectiveness of the presented methods.