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Karger Publishers, Hormone Research in Paediatrics, 2(80), p. 92-99, 2013

DOI: 10.1159/000351710

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Growth in Preterm Infants Until Six Months Postterm: The Role of Insulin and IGF-I

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

<b><i>Background/Aims:</i></b> Since insulin-like growth factor type I (IGF-I) and insulin regulate growth in term infants, they were studied in relation to nutrient intake and growth until 6 months corrected age (CA) in preterm infants. <b><i>Methods:</i></b> In 138 preterm infants (51% male, gestational age (expressed as median (IQR)) 30.6 (1.9) weeks, birth weight 1,368 (389) g) weight SDS, length SDS, IGF-I, and insulin were measured at term age, 3 and 6 months CA. <b><i>Results:</i></b> IGF-I and insulin at term age were associated with weight SDS and length SDS at term age and 3 months CA. IGF-I and insulin at 3 months CA were associated with weight SDS and length SDS at 3 and 6 months CA. IGF-I and insulin at term age were negatively associated with gain in weight SDS and gain in length SDS between term age and 6 months CA (IGF-I: β = -1.03, 95% CI -1.65;-0.41, p = 0.001 and β = -0.78, 95% CI -1.32;-0.23, p = 0.005; insulin: β = -0.19, 95% CI -0.37;-0.01, p = 0.044 and β = -0.18, 95% CI -0.35;-0.01, p = 0.035). Nutrient intake was not associated with IGF-I or insulin. <b><i>Conclusions:</i></b> The present study suggests that IGF-I and insulin are important growth regulators in preterm infants until 6 months CA, independent of nutrient intake.