Published in

Future Medicine, Future Microbiology, 3(11), p. 351-362, 2016

DOI: 10.2217/fmb.15.142

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Photodynamic inactivation of Candida albicans by hematoporphyrin monomethyl ether

Journal article published in 2016 by Chengcheng Liu, Min Hu, Xiaoyan Zeng, Sean P. Nair, Jiru Xu
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Aim: To evaluate the capacity of hematoporphyrin monomethyl ether (HMME) in the presence of light to cause photodynamic inactivation (PDI) of Candida albicans. Materials & methods: HMME photoactivity was evaluated against azole-susceptible and -resistant C. albicans. The mechanisms by which PDI of C. albicans occurred were also investigated. Results: HMME-mediated PACT caused a dose-dependent inactivation of azole-susceptible and -resistant C. albicans. Incubation with 10 μM HMME and irradiation with 72 J cm-2 light decreased the viability of C. albicans by 7 log10, induced damage of genomic DNA, led to loss of cellular proteins and damaged the cell wall, membrane and intracellular targets. Conclusion: Candida albicans can be effectively inactivated by HMME in the presence of light, and HMME-mediated PACT shows its potential as an antifungal treatment.