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American Academy of Neurology (AAN), Neurology, 13(86), p. 1217-1226, 2016

DOI: 10.1212/wnl.0000000000002528

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Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration

This paper is available in a repository.
This paper is available in a repository.

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Abstract

Objective: To investigate the influence of common and low-frequency genetic variants on the risk of ischemic stroke (all IS) and etiologic stroke subtypes. Methods: We meta-analyzed 12 individual genome-wide association studies comprising 10,307 cases and 19,326 controls imputed to the 1000 Genomes (1 KG) phase I reference panel. We selected variants showing the highest degree of association (p