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National Academy of Sciences, Proceedings of the National Academy of Sciences, 51(111), p. 18303-18308, 2014

DOI: 10.1073/pnas.1421815112

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Antagonist of GH-releasing hormone receptors alleviates experimental ocular inflammation

Journal article published in 2014 by Yong Jie Qin, Sun On Chan, Kelvin Kam Lung Chong ORCID, Benjamin Fuk Loi Li, Tsz Kin Ng ORCID, Yolanda Wong Ying Yip, Haoyu Chen ORCID, Mingzhi Zhang, Norman L. Block, Herman S. Cheung, Andrew V. Schally, Chi Pui Pang
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance We have shown that the growth hormone-releasing hormone–growth hormone–insulin-like growth factor-1 (GHRH–GH–IGF1) axis is involved in experimentally induced acute inflammation in the iris and ciliary body, where its activation is associated with inflammatory responses. Blocking GHRH–GH–IGF1 axis activity by the GHRH receptor (GHRH-R) antagonist is effective in alleviating inflammatory responses. These findings demonstrate a novel activity of GHRH–GH–IGF1 axis signaling in ocular inflammation and suggest a potential therapeutic application of GHRH-R antagonist.