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American Society for Microbiology, Journal of Bacteriology, 9(193), p. 2332-2335, 2011

DOI: 10.1128/jb.00027-11

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Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain

Journal article published in 2011 by Dhanalakshmi Nair, Guido Memmi, David Hernandez, Jonathan Bard ORCID, Marie Beaume, Steven Gill, Patrice Francois ORCID, Ambrose L. Cheung
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Staphylococcus aureus RN4220, a cloning intermediate, is sometimes used in virulence, resistance, and metabolic studies. Using whole-genome sequencing, we showed that RN4220 differs from NCTC8325 and contains a number of genetic polymorphisms that affect both virulence and general fitness, implying a need for caution in using this strain for such studies.