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BioMed Central, Journal of Clinical Bioinformatics, 1(3), p. 17, 2013

DOI: 10.1186/2043-9113-3-17

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The multiple roles of microRNA-155 in oncogenesis

Journal article published in 2013 by Gadareth Higgs, Frank Slack ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The microRNA miR-155 is prominent in cancer biology. Among microRNAs that have been linked to cancer, it is the most commonly overexpressed in malignancies (PNAS 109:20047-20052, 2012). Since its discovery, miR-155 has been implicated in promoting cancers of the breast, lung, liver, and lymphatic system. As such, targeted therapies may prove beneficial to cancer treatment. This review discusses the important role of miR-155 in oncogenesis. It synthesizes information from ten recent papers on miR-155, and includes an analysis and discussion of its association with cancer, interactions with other miRNAs, mechanisms of action, and the most promising available treatment options.