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Characterization and Differential Nuclear Localization of Nopp140 and a Novel Nopp140-Like Protein in Trypanosomes†

Journal article published in 2006 by S. Kelly ORCID, W. Singleton, B. Wickstead ORCID, K. Ersfeld, K. Gull
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Trypanosomatids possess two homologues of Nopp140: a canonical Nopp140 and a Nopp140-like protein (TbNoLP) in which a GAR domain replaces the C-terminal SRP40 domain. Both are phosphorylated and coimmunoprecipitate with RNA polymerase I. Each paralogue has a distinct subnuclear localization, and depletion of TbNoLP produces an enlarged nucleolus in which TbNopp140-containing regions disperse. The restricted occurrence pattern of NoLP proteins reflects an intriguing convergence in evolution, suggestive of a function in nucleoplasmic small nucleolar ribonucleoprotein shuttling.