The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X

Bentley, Dr R.; Hunt, Se E.; Deloukas, P.; Dunham, A.; French, L.; Gregory, Sg G.; Mungall, Aj J.; Humphray, Sj J.; Ross, Mt T.; Carter, Np P.; Dunham, I.; Scott, Ce E.; Ashcroft, Kj J.; Atkinson, Al L.; Aubin, K.; Beare, Dm M.; Bethel, G.; Brady, N.; Brook, Jc C.; Burford, Dc C.; Burrill, Wd D.; Burrows, C.; Butler, Ap P.; Carder, C.; Catanese, Jj J.; Clee, Cm M.; Clegg, Sm M.; Cobley, V.; Coffey, Aj J.; Cole, Cg G.; Collins, Je E.; Conquer, Js S.; Cooper, Ra A.; de Jong, Pj J.; Culley, Km M.; Dawson, E.; Dearden, Fl L.; Durbin, Rm M.; Dhami, Pd D.; Earthrowl, Me E.; Edwards, Ca A.; Evans, Rs S.; Gillson, Cj J.; Ghori, J.; Green, L.; Gwilliam, R.; Izmajlowicz, M.; Halls, Ks S.; Jones, Ca A.; Hammond, S.; Joseph, Ss S.; Harper, Gl L.; Laird, G.; Heathcott, Rw W.; Langford, Cf F.; Holden, Jl L.; Lehvaslaiho, Mh H.; Holloway, E.; Leversha, M. A.; Hopkins, Bl L.; McCann, Ot T.; Howard, Pj J.; McDonald, Lm M.; Howell, Gr R.; McDowall, J.; Huckle, Ej J.; Maslen, Gl L.; Hughes, Jennifer; Mistry, D.; Hunt, Pj J.; Moschonas, Nk K.; Hunt, Sarah E.; Neocleous, V.; Pearson, Dm M.; Phillips, Kj J.; Porter, Km M.; Prathalingam, S. R.; Ramsey, Yh H.; Ranby, Sa A.; Rice, Cm M.; Rogers, J.; Rogers, Lj J.; Sarafidou, T.; Scott, Dj J.; Sharp, Gj J.; Shaw-Smith, Cj J.; Smink, Lj J.; Soderlund, C.; Sotheran, Ec C.; Steingruber, He E.; Sulston, Je E.; Taylor, A.; Taylor, Rg G.; Thorpe, Aa A.; Tinsley, E.; Warry, Gl L.; Whittaker, A.; Whittaker, P.; Williams, Sh H.; Wilmer, Te E.; Wooster, R.; Wright, Cl L.

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Nature Research, Nature, 6822(409), p. 942-943, 2001

DOI: 10.1038/35057165

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The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X

Journal article published in 2001 by Dr R. Bentley, Se E. Hunt, P. Deloukas

, A. Dunham, L. French, Sg G. Gregory, Aj J. Mungall

, Sj J. Humphray, Mt T. Ross, Np P. Carter, I. Dunham

, Ce E. Scott, Kj J. Ashcroft, Al L. Atkinson, K. Aubin and other authors.

This paper is made freely available by the publisher.

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Abstract

We constructed maps for eight chromosomes (1, 6, 9, 10, 13, 20, X and (previously) 22), representing one-third of the genome, by building landmark maps, isolating bacterial clones and assembling contigs. By this approach, we could establish the long-range organization of the maps early in the project, and all contig extension, gap closure and problem-solving was simplified by containment within local regions. The maps currently represent more than 94% of the euchromatic (gene-containing) regions of these chromosomes in 176 contigs, and contain 96% of the chromosome-specific markers in the human gene map. By measuring the remaining gaps, we can assess chromosome length and coverage in sequenced clones.

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The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X

Abstract