Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

Yt, Chen; Okada, Yukinori; Sim, Xueling; Wu, Jer-Yuarn; Takeuchi, Fumihiko; Ys, Cho; Wild, S. H.; Takahashi, Atsushi; Ys, Aulchenko; Tsunoda, Tatsuhiko; Zhang, W.; Wh, Kao; Wh, van Gilst; V), (Salomaa; Wong, Tien-Yin; Sj, Fann; Young, Terri L.; Seielstad, Mark; Teo, Yik-Ying; Sj, Bakker; Zhang, Weihua; van der Harst, P.; Ng, Forouhi; de Silva, R.; Sehmi, J. S.; Tsai, Fuu-Jen; Wass, M. N.; Rt, Gansevoort; Chen, Y. T.; van der Heide, J. J.; Smith, G. D.; de Jong, P. E.; Chambers, J. C.; Rao, Dabeeru C.; Tanaka, Toshihiro; Ogihara, Toshio; Pe, de Jong; Rj, Loos; Nordfors, L.; Parsa, A.; Yamamoto, Kazuhiko; Pb, Munroe; Peltonen, L.; Penninx, B. W.; Perucha, E.; Pouta, A.; Prokopenko, I.; Nakamura, Yusuke; Roderick, P. J.; Ruokonen, A.; Pj, Roderick; Samani, N. J.; Sanna, S.; Nj, Samani; Schalling, M.; Schlessinger, D.; Schlieper, G.; Seelen,; Shuldiner, A. R.; Sjögren, M.; Td, Spector; Tai, E.-Shyong; Smit, J. H.; Snieder, H.; Ubink-Veltmaat, L. J.; Soranzo, N.; Johnson, T.; Uda, M.; Spector, T. D.; Stenvinkel, P.; Vollenweider, P.; Sternberg, M. J.; Wallace, C.; Swaminathan, R.; Zerres, K.; Waterworth, D.; Nj, Wareham; Waeber, G.; de Boer, I. H.; Wareham, N. J.; Ph, Maxwell; Zillikens, M. C.; de Andrade, M.; Scott, J.; Go, Min Jin; Nl, Glazer; Navis, G.; Ziegler, A.; Pattaro, C.; Gu, Dongfeng; Olden, M.; Sj, Hwang; Yang, Q.; Smith, A.; Maeda, Shiro; O'connell,; Schmidt, H.; Chen, S.; Schmidt, R.; Chen, Peng; Nm, Probst Hensch; Lim, Su-Chi; Teumer, A.; Zeller, T.; Paré, G.; Tb, Harris; Tanaka, T.; Probst-Hensch, N. M.; Tönjes, A.; Liu, Jianjun; Yy, Teo; Yj, Kim; Chambers, John C.; Rampersaud, E.; Struchalin, M.; Aung, Tin; St, Turner; Lord, G. M.; Ps, Wild; Lawlor, D. A.; Rb, Schnabel; van Duijn, C. M.; Tf, Munzel; Ts, Leak; Gale, D. P.; Siscovick, D.; Sc, Lim; Psaty, B. M.; Ahmadi, K. R.; Kim, Young Jin; Oostra,; Bakker, S. J.; Beckmann, J.; Province, M.; Wild, P. S.; Kooner, J. S.; Lee, Jong-Young; Bilo, H. J.; Turner, S. T.; Sh, Wild; Han, Bok-Ghee; Bochud, M.; Schillert, A.; Wilde, S.; Brown, M. J.; Kang, Daehee; Caulfield, M. J.; Chen, Chien-Hsiun; Connell, J. M.; Schnabel, R. B.; Cook, H. T.; Ty, Wong; Chang, Li-Ching; Cotlarciuc, I.; Wichmann, H. E.; Zgaga, L.; Deng, G.; Fann, S.-J. Cathy; Pm, Ridker; Zemunik, T.; Dikkeschei, L. D.; Sl, Kardia; Mei, Hao; Dimkovic, N.; Dockrell, M.; Zhao, J. H.; Tl, Young; Kooner, Jaspal S.; Zaboli, G.; Dominiczak, A.; Ebrahim, S.; Wright, A. F.; Hixson, James E.; Eggermann, T.; Farrall, M.; Devuyst, O.; Pp, Pramstaller; Ferrucci, L.; Schreiber, S.; Floege, J.; Uitterlinden, A. G.; Rivadeneira, F.; Forouhi, N. G.; Katsuya, Tomohiro; Gansevoort, R. T.; Ps, Middelberg; Nitsch, D.; Han, X.; Hedblad, B.; Isono, Masato; Hepkema, B. G.; Mägi, R.; Hernandez Fuentes, M.; Stumvoll, M.; Hypponen, E.; Völzke, H.; Kleefstra, N.; Om, Woodward; Völker, U.; Lapsley, M.; Nauck, M.; Li, Y.; Vitart,; Loos, R. J.; Polasek, O.; Luan, J.; Lagou,; Ng, Martin; Albrecht, Eva; Luttropp, K.; Parker, A. N.; Maréchal, C.; Ridker, P. M.; Melander, O.; Munroe, P. B.; Singleton, A.; Wang, W.; Rochat, T.; Rj, Scott; Paulweber, B.; Kubo, Michiaki; Rp, Stolk; Shlipak, M. G.; Kato, Norihiro; Rm, Plenge; Wilson, J. F.; Kamatani, Naoyuki; Feitosa, M.; Rudan, I.; Witteman, J. C.; Sm, Farrington; He, Jiang; Sy, Shin; Shyong Tai, E.; Pramstaller, P. P.; Rettig, R.; Cho, Yoon Shin; Vitart, V.; Maxwell, P. H.; Mj, Go; McCarthy, M. I.; Ch, Chen; Fj, Tsai; Pistis, G.; Jarvelin, M. R.; Lc, Chang; Ruggiero, D.; Mooser, V.; Dc, Rao; O'seaghdha, M.; Abecasis, G. R.; Je, Hixson; Lightstone, L.; van Gilst, W. H.; Jc, Chambers; Js, Kooner; Shi, J.; Elliott, P.; Es, Tai; Gm, Lord; Köttgen, A.; von Eckardstein, A.; Da, Lawlor; Js, Sehmi; Böger, C. A.; Pirastu, N.; Dp, Gale; Fuchsberger, C.; Mn, Wass; Yengo, L.; Glazer, N. L.; Kr, Ahmadi; Gao, X.; Hj, Bilo; Li, M.; Isaacs, A.; Ketkar, S.; Nolte, I. M.; Hwang, S. J.; Johnson, A. D.; Mj, Brown; Dehghan, A.; Peden, J. F.; Atkinson, E. J.; Steri, M.; Tenesa, A.; Lohman, K.; Salo, P.; Woodward, O. M.; Mj, Caulfield; Cornelis, M. C.; Rose, L. M.; Kronenberg, F.; Jm, Connell; Hayward, C.; Tin, A.; Müller, C.; Ht, Cook; Aspelund, T.; Campbell, S.; Oldmeadow, C.; Eiriksdottir, G.; Putku, M.; Launer, L. J.; Harris, T. B.; Gd, Smith; Thun, G. A.; Mitchell, B. D.; Arking, D. E.; Boerwinkle, E.; Cavalieri, M.; Schallert, M.; Ld, Dikkeschei; Giallauria, F.; Metter, J.; Haritunians, T.; Ulivi, S.; Lumley, T.; Rotter, J. I.; Navaro, P.; Jy, Wu; Munzel, T. F.; Leak, T. S.; Illig, T.; Salumets, A.; Klopp, N.; Meisinger, C.; Zhang, Q.; Koenig, W.; Scott, R. J.; Viigimaa, M.; Org, E.; Kolcic, I.; Minelli, C.; Jj, van der Heide; Hu, F. B.; Johansson, Å.; Trabetti, E.; Bg, Hepkema; Igl, W.; Sorice, R.; Waldenberger, M.; Campbell, H.; Strauch, K.; Ellinghaus, D.; Theis, F.; Albrecht, E.; Aulchenko, Y. S.; Felix, J. F.; Winkelmann, B. R.; Stolk, R. P.; Hofman, A.; Imboden, M.; Brandstätter, A.; Plenge, R. M.; Kollerits, B.; Bw, Penninx; Portas, L.; Persico, I.; Kedenko, L.; Kovacs, P.; Boban, M.; Ongen, H.; Endlich, K.; Kroemer, H. K.; Nagaraja, R.; Ma, Seelen; Piras, M. G.; Schurmann, C.; Ar, Shuldiner; Badola, S.; Kardia, S. L.; Theodoratou, E.; Blankenberg, S.; Liu, Y.; Perola, M.; Jh, Smit; Curhan, G. C.; Salomaa, V.; Viikari, J.; Shin, S. Y.; Franke, A.; Sala, C.; Gudnason,; Coresh, J.; Nelson, C. P.; Nalls,; Sharma, P.; Borecki, I.; Krämer, B. K.; Gyllensten, U.; Mj, Sternberg; Lj, Ubink Veltmaat; Pirastu, M.; Hastie, N.; Chasman, D. I.; Tore, S.; Kao, W. H.; Heid, I. M.; Whitfield, J. B.; Mi, McCarthy; Fox, C. S.; Mr, Jarvelin; Krumsiek, J.; Siscovick, D. S.; Hundertmark, C.; Gr, Abecasis; Haller, T.; Wolffenbuttel, B. H.; Ca, Böger; Kutalik, Z.; März, W.; Middelberg, P. S.; Watkins, H.; Gaffo, A. L.; Av, Smith; Li, G.; Schipf, S.; Huffman, J.; Ripatti, S.; Jr, O'Connell; Toniolo, D.; Demirkan, A.; Raitakari, O.; Liu, X.; Malerba, G.; Lopez, L. M.; Kubo, M.; Li, X.; Nakamura, Y.; Kleber, M. E.; Ad, Johnson; Hicks, A. A.; Johansson, A.; Ej, Atkinson; Mc, Cornelis; Lagou, V.; Mangino, M.; Lj, Launer; Lehtimäki, T.; Czamara, D.; Bd, Mitchell; Kraft, P.; Frogheri, L.; Grotevendt, A.; De, Arking; Gislason, G. K.; McArdle, P.; Ih, de Boer; Bm, Psaty; Martin, N. G.; Montgomery, G. W.; Mc, Zillikens; Ba, Oostra; Murgia, Federico; Jacobs, D. R.; Chen, Shufeng; Liu, K.; D'Adamo, P.; Devuyst, Olivier; Balkau, B.; He, Wichmann; Froguel, P.; Esko, T.; Cathy Fann, S. J.; Khaw, K. T.; Fb, Hu; Langenberg, C.; Af, Wright; Kraja, A.; Jf, Felix; Holliday, E. G.; Bandinelli, S.; Ag, Uitterlinden; Metter, J. E.; Lupo, A.; Hk, Kroemer; Döring, A.; Lattka, E.; An, Parker; Gc, Curhan; Davies, G.; Gow, A. J.; Mg, Shlipak; Bruinenberg, M.; Cm, van Duijn; Bk, Krämer; Boehm, B. O.; Lucae, S.; Jf, Wilson; Curhan, G.; Mudgal, P.; Jc, Witteman; Di, Chasman; Kirin, M.; Im, Heid; Mateo Leach, I.; Cs, Fox; Goel, A.; Al, Gaffo; Jh, Zhao; Cucca, F.; Mf, Feitosa; Budde, K.; Lm, Lopez; Ernst, F.; Me, Kleber; Farrington, S. M.; Aa, Hicks; Jy, Lee; Jula, A.; Kamatani, N.; Im, Nolte; Kähönen, M.; Consortium, KidneyGen; Jf, Peden; Hengstenberg, C.; Lm, Rose; Meschia, J. F.; Ga, Thun; Gk, Gislason; Burnier, M.; Bg, Han; Attia, J.; Laan, M.; Gw, Montgomery; Dr, Jacobs; Hillege, H. L.; Kloiber, S.; Ji, Rotter; Choi, H.; Kt, Khaw; Gudnason, V.; Consortium, CKDGen; Eg, Holliday; Fornage, M.; Gasparini, P.; Je, Metter; Aj, Gow; Bouatia Naji, N.; Gugc, Consortium; Metspalu, A.; Borecki, I. B.; Chen, Yuan-Tsong; Gambaro, G.; Br, Winkelmann; Deary, I. J.; Bo, Boehm; Mg, Piras; Cp, Nelson; Jf, Meschia; Ma, Nalls; Dunlop, M. G.; Ab, Singleton; Hl, Hillege; Jb, Whitfield; Ds, Siscovick; Ib, Borecki; Ij, Deary; Bh, Wolffenbuttel; Ciullo, M.; Mg, Dunlop; Caulfield, M.; Gieger, C.

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Nature Research, Nature Genetics, 8(44), p. 904-909, 2012

DOI: 10.1038/ng.2352

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Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

Journal article published in 2012 by Chen Yt, Yukinori Okada, Xueling Sim, Jer-Yuarn Wu, Fumihiko Takeuchi, Cho Ys, S. H. Wild, Atsushi Takahashi, Aulchenko Ys, Tatsuhiko Tsunoda, W. Zhang, Kao Wh, van Gilst Wh, (Salomaa V), Tien-Yin Wong and other authors.

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Abstract

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

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Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

Abstract