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Relaxin: Review of Biology and Potential Role in Treating Heart Failure

Journal article published in 2010 by Sam L. Teichman, Elaine Unemori, John R. Teerlink, Gad Cotter, Marco Metra ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Relaxin is a naturally occurring human peptide initially identified as a reproductive hormone. More recently, relaxin has been shown to play a key role in the maternal hemodynamic and renal adjustments that accommodate pregnancy. An understanding of these physiologic effects has led to the evaluation of relaxin as a pharmacologic agent for the treatment of patients with acute heart failure. Preliminary results have been encouraging. In addition, the other known biologic properties of relaxin, including anti-inflammatory effects, extracellular matrix remodeling effects, and angiogenic and anti-ischemic effects, all may play a role in potential benefits of relaxin therapy. Ongoing, large-scale clinical testing will provide additional insights into the potential role of relaxin in the treatment of heart failure.