Aiming at the damage of package caused by emergency rescue and other severe transportation environment, a multi-level cushioning packaging storage box is proposed in this paper, the precise instrument is fixed in the box, which achieves the box-instrument integration. At the moment when air-dropped box touches the ground, the impact force is absorbed and cushioned through plastic cork base, rubber absorber, box body, steel wire rope spring, hydraulic damper for five times, which could provide effective cushion protection for the precise instrument which fragility value is not less than 15G. Simulation airdrop tests are performed to the storage box with different cushion levels, and the test shows that the result of five-level cushion method proposed in the paper is the best, and overload values are all within 12G, which could provide enough cushion space for precise instrument to avoid touchdown damage.