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Trans Tech Publications, Advanced Materials Research, (602-604), p. 1215-1218, 2012

DOI: 10.4028/www.scientific.net/amr.602-604.1215

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Preparation of Vitamin C Dripping Pill and its Quality Evaluation

Journal article published in 2012 by Xiao Lin Xu, Qing Zhu, Tian Ze Bian, Ke Hai Liu ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

[Objective] to study the modeling technique of Vitamin C dripping pill and its quality evaluation. [Method] the preparation conditions were optimized by orthogonal experiments using encapsulation efficiency (EE) as the target index. The matrix type (PEG 4000:PEG 6000), ratio of drug to matrix, dripping temperature and dripping distance with three levels were chosen in the orthogonal experiments. Weight variation, dispersion limit, content and stability of the dripping pill under the optimum conditions were estimated. [Results] The optimum conditions were obtained when matrix type (PEG 4000: PEG 6000), ratio of drug to matrix, dripping temperature and dripping distance were 6:1, 1:7, 80 °C and 20 cm respectively. The weight variation and dispersion limit of the dripping pill ranged in -13.47-13.38% and 4.5-5.0min. An assay method was developed by UV spectrophotometry. Its quality was stable during the three months of accelerated test. [Conclusion] the weight variation and dispersion limit of the dripping pill with good morphology and high stability came up to the requirements of Ch. P, the assay method was simple and accurate, demonstrating that the dripping pill can be used as edible or pharmaceutical dosage form.