Published in
Royal Society of Chemistry, RSC Advances, 91(5), p. 74605-74610, 2015
DOI: 10.1039/c5ra08551a
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Identification of disulfide isomerase ERp57 as a target for small molecule cardioprotective agents
Journal article published in 2015 by
Guozhen Cui,
Luchen Shan,
Ivan Keung Chu,
Guohui Li,
George Pak Heng Leung,
Gph Leung,
Yuqiang Wang,
Yw Kwan,
Simon Ming Yuen Lee,
Yiu Wa Kwan,
Sw Chan,
Shun Wan Chan 
,
Pm Hoi,
Maggie Pui Man Hoi,
My Lee
,
Pm Hoi,
Maggie Pui Man Hoi,
My Lee
This paper is made freely available by the publisher.
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Abstract
Compound BAA exhibited protective effect against oxidative stress-induced cells injury in H9c2 cardiomyoblast. Chemical proteomic approach identified ERp57 as the specific target for BAA. Furthermore, BAA displayed potent inhibitory effect on the catalytic activity of ERp57.