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American Academy of Neurology (AAN), Neurology, 4(84), p. 382-390, 2014

DOI: 10.1212/wnl.0000000000001182

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IQ at 6 years after in utero exposure to antiepileptic drugs

Journal article published in 2015 by Gus A. Baker, Rebecca L. Bromley, Maria Briggs, Christopher P. Cheyne, Morris J. Cohen, Marta García-Fiñana, Alison Gummery, Rachel Kneen, David W. Loring ORCID, George Mawer, Kimford J. Meador, Rebekah Shallcross ORCID, Claire Barrie, John Beech, Jill Clayton-Smith and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

OBJECTIVE: To delineate the risk to child IQ associated with frequently prescribed antiepileptic drugs. METHODS: Children born to women with epilepsy (n = 243) and women without epilepsy (n = 287) were recruited during pregnancy and followed prospectively. Of these, 408 were blindly assessed at 6 years of age. Maternal and child demographics were collected and entered into statistical models. RESULTS: The adjusted mean IQ was 9.7 points lower (95% confidence interval [CI] -4.9 to -14.6; p 800 mg daily) valproate, with a similar significant effect observed for the verbal, nonverbal, and spatial subscales. Children exposed to high-dose valproate had an 8-fold increased need of educational intervention relative to control children (adjusted relative risk, 95% CI 8.0, 2.5-19.7; p