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EMBO Press, The EMBO Journal, 13(31), p. 2837-2838

DOI: 10.1038/emboj.2012.140

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Untangling the mysteries of maternal inheritance with polyCOMB: Material inheritance with polyCOMB

Journal article published in 2012 by Roopsha Sengupta, M. Azim Surani ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The inheritance of maternal factors in oocytes plays a crucial role in development, particularly in non-mammalian species, where asymmetric segregation of developmental factors among early blastomeres regulates early patterning of the embryo. Whereas this role is less important in mammals, a number of studies have shown that maternal inheritance is equally critical for regulating development through epigenetic instructions and initiating transition from the zygote to embryonic transcription programme (Li et al, 2010). A recent study by Posfai et al (2012) now shows the important role played by maternally inherited Polycomb complexes during development of the mouse oocyte, and thereafter during early development.