Background: The course of fatigue and quality of life in non-Hodgkin lymphoma survivors is unknown. Therefore, the aims were to assess fatigue and quality of life following primary treatment, compare fatigue and quality of life with an age- and sex matched normative population to assess the severity of concerns and identify associations with fatigue of survivors who remained fatigued. Methods: The population-based Eindhoven Cancer Registry was used to select all patients diagnosed with non-Hodgkin lymphoma from 1999-2009. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and the Fatigue Assessment Scale were completed once by 824 non-Hodgkin lymphoma survivors (80% response rate), subsequently 434 survivors completed these questionnaires again one year later. Results: Non-Hodgkin lymphoma survivors reported more clinically relevant fatigue up till 10 years post-diagnosis compared to a normative population (p<.001). Fatigue mean scores remained rather stable over time (T1: =28, SD=26; T2: =30, SD=27,p=.14), 22-28% of survivors reported deterioration and 19-23% improvement; 44-54% reported constant fatigue. Survivors who reported constant fatigue were more often diagnosed with stage IV disease and had more comorbid diseases. They were additionally more often female and divorced. Having comorbidities and being without partner were also associated with remained fatigue in the normative population. Conclusion: Six out of 10 of responding non-Hodgkin lymphoma survivors reported a high level of fatigue up till 10 years after diagnosis. Fatigue mean scores remained stable over time and survivors reporting constant fatigue more often exhibited stage IV disease and comorbidities.