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EMBO Press, EMBO Reports, 9(14), p. 780-787, 2013

DOI: 10.1038/embor.2013.102

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ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon

Journal article published in 2013 by Jenish R. Patel, Ankur Jain, Yi-Ying Chou, Alina Baum, Taekjip Ha ORCID, Adolfo García-Sastre
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

This study shows that RIG-I oligomerizes on Sendai virus-derived RNA in an ATP hydrolysis and dsRNA length dependent manner. Oligomerization correlates with the strength of interferon activation, thus identifying the role of the elusive RIG-I ATPase activity.