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Nature Research, Nature Communications, 1(5), 2014

DOI: 10.1038/ncomms5613

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Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

Journal article published in 2014 by Brent W. Zanke, Hansong Wang, Terrilea Burnett, Suminori Kono, Christopher A. Haiman, Motoki Iwasaki, David Van Den Berg, Lynne R. Wilkens, Lenora W. M. Loo, Laurence N. Kolonel, Brian E. Henderson, Temitope O. Keku, Robert S. Sandler, Sonja I. Berndt, John A. Baron and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P