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Springer, Human Genetics, 6(134), p. 539-551, 2014

DOI: 10.1007/s00439-014-1514-5

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Heritability and genome-wide analyses of problematic peer relationships during childhood and adolescence

Journal article published in 2014 by Beate St Pourcain ORCID, C. M. A. Haworth, O. S. P. Davis, Kai Wang, Nicholas J. Timpson ORCID, David M. Evans, John P. Kemp, Angelica Ronald, Tom Price ORCID, Emma Meaburn, Susan M. Ring, Jean Golding, Hakon Hakonarson, R. Plomin ORCID, George Davey Smith and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Peer behaviour plays an important role in the development of social adjustment, though little is known about its genetic architecture. We conducted a twin study combined with a genome-wide complex trait analysis (GCTA) and a genome-wide screen to characterise genetic influences on problematic peer behaviour during childhood and adolescence. This included a series of longitudinal measures (parent-reported Strengths-and-Difficulties Questionnaire) from a UK population-based birth-cohort (ALSPAC, 4–17 years), and a UK twin sample (TEDS, 4–11 years). Longitudinal twin analysis (TEDS; N ≤ 7,366 twin pairs) showed that peer problems in childhood are heritable (4–11 years, 0.60