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Society of Nuclear Medicine, Journal of Nuclear Medicine, 8(50), p. 1356-1363, 2009

DOI: 10.2967/jnumed.108.060822

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Serial Noninvasive Targeted Imaging of Peripheral Angiogenesis: Validation and Application of a Semiautomated Quantitative Approach

Journal article published in 2009 by Lawrence W. Dobrucki ORCID, Donald P. Dione, Leszek Kalinowski, Donna Dione, Marivi Mendizabal, Jun Yu, Xenophon Papademetris, William C. Sessa, Albert J. Sinusas
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Previous studies by our group have demonstrated the feasibility of non-invasive imaging of αv integrin to assess temporal and spatial changes in peripheral and myocardial angiogenesis. In this study we validate the reproducibility, accuracy, and applicability of a new semi-automated non-invasive approach for serial quantitative evaluation of targeted microSPECT-CT images of peripheral angiogenesis in wild-type and eNOS-deficient mice subjected to hindlimb ischemia.