New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Yvonne,; van Hoek, Mandy; van Duijn, Cornelia M.; Dupuis, Josee; Langenberg, Claudia; Prokopenko, Inga; Jackson, Anne U.; Saxena, Richa; Glazer, Nicole L.; Teresa Martinez-Larrad, Maria; Mägi, Reedik; Gloyn, Anna L.; Johnson, Toby; Lindgren, Cecilia M.; M&amp;auml;gi, Reedik; Soranzo, Nicole; Morris, Andrew P.; Jj, Hottenga; Sigurosson, Gunnar; Elliott, Paul; Wheeler, Eleanor; Cs, Franklin; Thomas,; Grallert, Harald; Dehghan, Abbas; Jr, Perry; Jm, Egan; Christine,; Bouatia-Naji, Nabila; JanHottenga, J.; Tönjes, Anke; Navarro, Pau; Franklin, Christopher S.; Song, Kijoung; Bf, Voight; Hottenga, Jouke Jan; Goel, Anuj; Hm, Stringham; Jeffrey,; Lajunen, Taina; Perry, John R. B.; Grarup, Niels; Egan, Josephine M.; Zabena, Carina; Au, Jackson; Sparsø, Thomas; Doney, Alex S. F.; Yd, Chen; Nj, Timpson; Voight, Benjamin F.; Li, Man; Randall, Joshua; Kanoni, Stavroula; Stringham, Heather M.; Shrader, Peter; Cavalcanti-Proença, Christine; Sa, McCarroll; Kumari, Meena; Rm, Roccasecca; Qi, Lu; Gieger, Christian; Nl, Glazer; Timpson, Nicholas J.; Rocheleau, Ghislain; de Geus, Eco J. C.; Rybin, Denis; Ingelsson, Erik; An, Ping; Jp, Beilby; O'Connell, Jeffrey; Thorleifsson, Gudmar; Aj, Bennett; Luan, Jian’an; Elliott, Amanda; McCarroll, Steven A.; Payne, Felicity; Steinthorsdottir, Valgerdur; Ll, Bonnycastle; Pattou, François; Roccasecca, Rosa Maria; Henneman, Peter; Sethupathy, Praveen; Ap, Morris; Al, Gloyn; Ardlie, Kristin; Ya, Kesaniemi; Ariyurek, Yavuz; Sj, Bumpstead; Balkau, Beverley; Barter, Philip; Lj, Coin; Beilby, John P.; Benediktsson, Rafn; Ben-Shlomo, Yoav; Cm, Lindgren; Mn, Cooper; Bennett, Amanda J.; Bergmann, Sven; Bochud, Murielle; In, Day; Boerwinkle, Eric; Der IdaChen, Y.; Bonnefond, Amélie; Ej, de Geus; McOin, L. J.; Borch-Johnsen, Knut; Bonnycastle, Lori Ll; Böttcher, Yvonne; Mr, Erdos; Brunner, Eric; Ac, Fedson; Torben,; Charpentier, Guillaume; Bumpstead, Suzannah J.; Chen, Yii-Der Ida; Ng, Forouhi; Chines, Peter; De Geus, E. J. C.; Clarke, Robert; Cs, Fox; Coin, Lachlan J. M.; Cornelis, Marilyn; Mg, Franzosi; Cooper, Matthew N.; Crawford, Gabe; Antero Kesaniemi, Y.; Mo, Goodarzi; Crisponi, Laura; Cj, Groves; Delplanque, Jerome; GraziaFranzosi, M.; Day, Ian N. M.; Dina, Christian; Erdos, Michael R.; Fischer-Rosinsky, Antje; Al, Hartikainen; Fedson, Annette C.; Forouhi, Nita G.; Mark Lathrop, G.; Sc, Heath; Frants, Rune; Fox, Caroline S.; Galan, Pilar; Franzosi, Maria Grazia; -LiisaHartikainen, A.; Aa, Hicks; Graessler, Jürgen; Goodarzi, Mark O.; Dr, Hillman; Grundy, Scott; Gwilliam, Rhian; Groves, Christopher J.; Ad, Hingorani; Gyllensten, Ulf; Hadjadj, Samy; Pr, Johnson; Hallmans, Göran; Hammond, Naomi; Zethelius, Bj; Han, Xijing; Hartikainen, Anna-Liisa; Hassanali, Neelam; Hayward, Caroline; van Dijk, Ko Willems; Ko, Kyvik; Hercberg, Serge; AnteroKesaniemi, Y.; Heath, Simon C.; Herder, Christian; Gm, Lathrop; Hicks, Andrew Aa; Da, Lawlor; Hofman, Albert; Hillman, David R.; Mägi, Reedik; Hui, Jennie; Hingorani, Aroon D.; Bacquer, Olivier Le; Wild, Sarah H.; Witteman, Jaqueline C. M.; Hung, Joe; Ak, Manning; Yarnell, John W. G.; Mt, Martínez Larrad; Isomaa, Bo; Jørgensen, Torben; Jb, McAteer; Jula, Antti; Zillikens, Mc Carola; Zhao, Jing Hua; Kaakinen, Marika; Johnson, Paul R. V.; Lj, McCulloch; Kaprio, Jaakko; Kivimaki, Mika; Bd, Mitchell; Williams, Gordon H.; Knight, Beatrice; Kesaniemi, Ya Antero; Koskinen, Seppo; Ma, Morken; Kovacs, Peter; Mj, Neville; Kyvik, Kirsten Ohm; Ba, Oostra; Marco,; Le Bacquer, Olivier; Lathrop, Gm Mark; Lecoeur, Cecile; Cn, Palmer; Li, Yun; Lawlor, Debbie A.; Lyssenko, Valeriya; Ys, Aulchenko; Mahley, Robert; Jf, Peden; Mangino, Massimo; APalmer, C. N.; Manning, Alisa K.; Nl, Pedersen; Martínez-Larrad, María Teresa; Af, Pfeiffer; Wichmann, He Erich; McPherson, Ruth; McAteer, Jarred B.; Meisinger, Christa; Wright, Alan F.; Sc, Potter; McCulloch, Laura J.; Melzer, David; Ma, Province; Wilson, James F.; Meyre, David; Bm, Psaty; Mukherjee, Sutapa; Mitchell, Braxton D.; Naitza, Silvia; Morken, Mario A.; Nw, Rayner; Sijbrands, Erik J. G.; Narisu, Narisu; Neville, Matthew J.; Orru, Marco; Aa, Sayer; Pakyz, Ruth; Oostra, Ben A.; Paolisso, Giuseppe; Lj, Scott; Sigurethsson, Gunnar; Pattaro, Cristian; Palmer, Colin N. A.; O’Connell, Jeffrey; Pearson, Daniel; Sj, Sharp; Ej, Sijbrands; Peden, John F.; Perola, Markus; Pedersen, Nancy L.; Pichler, Irene; Polasek, Ozren; Pfeiffer, Andreas F. H.; Sigursson, G.; Nl, Smith; Posthuma, Danielle; Boettcher, Yvonne; Willemsen, Gonneke; Magi, Reedik; Pouta, Anneli; Potter, Simon C.; Ac, Syvänen; Zeggini, Eleftheria; Rathmann, Wolfgang; Province, Michael A.; Zelenika, Diana; -ChristineSyvänen, A.; Psaty, Bruce M.; Ag, Uitterlinden; Zhai, Guangju; Rice, Kenneth; Ripatti, Samuli; Kw, van Dijk; Rivadeneira, Fernando; Gunnar,; Rayner, Nigel W.; Roden, Michael; Rolandsson, Olov; Syv&amp;auml;nen, Ann-Christine; Sandbaek, Annelli; Pj, Wagner; Sandhu, Manjinder; Van Dijk, K. W.; Sanna, Serena; Hoek, M.; Scheet, Paul; Gb, Walters; Sayer, Avan Aihie; Seedorf, Udo; Kl, Ward; Scott, Laura J.; Shields, Beverley; Mn, Weedon; Sharp, Stephen J.; Sh, Wild; Silveira, Angela; Anke,; Simpson, Laila; BragiWalters, G.; Singleton, Andrew; Jc, Witteman; Sigurðsson, Gunnar; Jw, Yarnell; Böttcher, Yvonne; Sovio, Ulla; Swift, Amy; Smith, Nicholas L.; Syddall, Holly; Jh, Zhao; Bragi Walters, G.; Tanaka, Toshiko; MWitteman, J. C.; Thorand, Barbara; GYarnell, J. W.; Mc, Zillikens; Tichet, Jean; Tönjes, Anke; Ib, Borecki; Syvanen, Ann-Christine; Rj, Loos; Tuomi, Tiinamaija; Jorgensen, Torben; Consortium, Global BPgen; Pk, Magnusson; Dm, Nathan; Varma, Dhiraj; Uitterlinden, Andre G.; Carola Zillikens, M.; Gh, Williams; At, Hattersley; Visvikis-Siest, Sophie; Vitart, Veronique; Diagram, Consortium; Giant, Consortium; Vogelzangs, Nicole; Gd, Smith; Waeber, Gerard; Sr, Bornstein; Ar, Shuldiner; Walley, Andrew; Gv, Dedoussis; Ad, Morris; Wagner, Peter J.; Watkins, Hugh; Ward, Kim L.; Lj, Palmer; Walters, Gb Bragi; Fb, Hu; Weedon, Michael N.; Pw, Franks; Wh, Kao; Linda Kao, W. H.; Js, Pankow; Mj, Sampson; Pedersen, Oluf; Borecki, Ingrid B.; Meneton, Pierre; Pp, Pramstaller; Loos, Ruth J. F.; He, Wichmann; Af, Wright; Magnusson, Patrik K. E.; Nathan, David M.; Silander, Kaisa; Jf, Wilson; Bergman, Richard N.; Salomaa, Veikko; Hattersley, Andrew T.; Buchanan, Thomas A.; Rn, Bergman; Schwarz, Peter; Collins, Francis S.; Spranger, Joachim; Ta, Buchanan; Bornstein, Stefan R.; Smith, George Davey; Mohlke, Karen L.; Fs, Collins; Karpe, Fredrik; Palmer, Lyle J.; Kl, Mohlke; Tt, Valle; Cooper, Cyrus; Valle, Timo Tt; Shuldiner, Alan R.; Serrano-Ríos, Manuel; Magic, Investigators; Ji, Rotter; Dedoussis, George V.; Lind, Lars; Erich Wichmann, H.; Morris, Andrew D.; Ds, Siscovick; Consortium, Anders Hamsten on behalf of Procardis; Tuomilehto, Jaakko; Ebrahim, Shah; Bw, Penninx; Rotter, Jerome I.; Hu, Frank B.; Altshuler, David; Marmot, Michael; Franks, Paul W.; Siscovick, David S.; Penninx, Brenda W. J. H.; Di, Boomsma; Boomsma, Dorret I.; Manuel,; Td, Spector; Kuusisto, Johanna; Kao, Wh H. Linda; Laakso, Markku; Spector, Timothy D.; Pankow, James S.; Deloukas, Panos; Davey Smith, George; Hansen, Torben; Tm, Frayling; Frayling, Timothy M.; Sampson, Michael J.; Ferrucci, Luigi; Kong, Augustine; Thorsteinsdottir, Unnur; Stefansson, Kari; Van Duijn, C. M.; Cm, van Duijn; Illig, Thomas; Aulchenko, Yurii S.; Cao, Antonio; Scuteri, Angelo; Rudan, Igor; Jarvelin, Marjo-Riitta; Schlessinger, David; Pramstaller, Peter Paul; Mr, Jarvelin; Uda, Manuela; Stumvoll, Michael; Ruokonen, Aimo; Hamsten, Anders; Campbell, Harry; -RiittaJarvelin, M.; Dm, Waterworth; Waterworth, Dawn M.; Vollenweider, Peter; Peltonen, Leena; Gr, Abecasis; Mooser, Vincent; Abecasis, Gonçalo R.; Wareham, Nicholas J.; Nj, Wareham; Sladek, Robert; Rm, Watanabe; Froguel, Philippe; Watanabe, Richard M.; Jb, Meigs; Consortiu, Anders Hamsten Procardis; Meigs, James B.; Groop, Leif; Boehnke, Michael; Mi, McCarthy; McCarthy, Mark I.; Anders Hamsten Procardis Consortiu, Global BPgen Consortium GIANT Consortium DIAGRAM Consortium MAGIC Investigators; Florez, Jose C.; Jc, Florez; Barroso, Inês; ,

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Yvonne et al., 2010

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@article{Yvonne2010,
  abstract = {Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes. ; Josée Dupuis . Lyle J Palmer . et al.},
  author = {Yvonne,  and van Hoek, Mandy and van Duijn, Cornelia M. and Dupuis, Josee and Langenberg, Claudia and Prokopenko, Inga and Jackson, Anne U. and Saxena, Richa and Glazer, Nicole L. and Teresa Martinez-Larrad, Maria and Mägi, Reedik and Gloyn, Anna L. and Johnson, Toby and Lindgren, Cecilia M. and M&amp;auml;gi, Reedik and Soranzo, Nicole and Morris, Andrew P. and Jj, Hottenga and Sigurosson, Gunnar and Elliott, Paul and Wheeler, Eleanor and Cs, Franklin and Thomas,  and Grallert, Harald and Dehghan, Abbas and Jr, Perry and Jm, Egan and Christine,  and Bouatia-Naji, Nabila and JanHottenga, J. and Tönjes, Anke and Navarro, Pau and Franklin, Christopher S. and Song, Kijoung and Bf, Voight and Hottenga, Jouke Jan and Goel, Anuj and Hm, Stringham and Jeffrey,  and Lajunen, Taina and Perry, John R. B. and Grarup, Niels and Egan, Josephine M. and Zabena, Carina and Au, Jackson and Sparsø, Thomas and Doney, Alex S. F. and Yd, Chen and Nj, Timpson and Voight, Benjamin F. and Li, Man and Randall, Joshua and Kanoni, Stavroula and Stringham, Heather M. and Shrader, Peter and Cavalcanti-Proença, Christine and Sa, McCarroll and Kumari, Meena and Rm, Roccasecca and Qi, Lu and Gieger, Christian and Nl, Glazer and Timpson, Nicholas J. and Rocheleau, Ghislain and de Geus, Eco J. C. and Rybin, Denis and Ingelsson, Erik and An, Ping and Jp, Beilby and O'Connell, Jeffrey and Thorleifsson, Gudmar and Aj, Bennett and Luan, Jian’an and Elliott, Amanda and McCarroll, Steven A. and Payne, Felicity and Steinthorsdottir, Valgerdur and Ll, Bonnycastle and Pattou, François and Roccasecca, Rosa Maria and Henneman, Peter and Sethupathy, Praveen and Ap, Morris and Al, Gloyn and Ardlie, Kristin and Ya, Kesaniemi and Ariyurek, Yavuz and Sj, Bumpstead and Balkau, Beverley and Barter, Philip and Lj, Coin and Beilby, John P. and Benediktsson, Rafn and Ben-Shlomo, Yoav and Cm, Lindgren and Mn, Cooper and Bennett, Amanda J. and Bergmann, Sven and Bochud, Murielle and In, Day and Boerwinkle, Eric and Der IdaChen, Y. and Bonnefond, Amélie and Ej, de Geus and McOin, L. J. and Borch-Johnsen, Knut and Bonnycastle, Lori Ll and Böttcher, Yvonne and Mr, Erdos and Brunner, Eric and Ac, Fedson and Torben,  and Charpentier, Guillaume and Bumpstead, Suzannah J. and Chen, Yii-Der Ida and Ng, Forouhi and Chines, Peter and De Geus, E. J. C. and Clarke, Robert and Cs, Fox and Coin, Lachlan J. M. and Cornelis, Marilyn and Mg, Franzosi and Cooper, Matthew N. and Crawford, Gabe and Antero Kesaniemi, Y. and Mo, Goodarzi and Crisponi, Laura and Cj, Groves and Delplanque, Jerome and GraziaFranzosi, M. and Day, Ian N. M. and Dina, Christian and Erdos, Michael R. and Fischer-Rosinsky, Antje and Al, Hartikainen and Fedson, Annette C. and Forouhi, Nita G. and Mark Lathrop, G. and Sc, Heath and Frants, Rune and Fox, Caroline S. and Galan, Pilar and Franzosi, Maria Grazia and -LiisaHartikainen, A. and Aa, Hicks and Graessler, Jürgen and Goodarzi, Mark O. and Dr, Hillman and Grundy, Scott and Gwilliam, Rhian and Groves, Christopher J. and Ad, Hingorani and Gyllensten, Ulf and Hadjadj, Samy and Pr, Johnson and Hallmans, Göran and Hammond, Naomi and Zethelius, Bj and Han, Xijing and Hartikainen, Anna-Liisa and Hassanali, Neelam and Hayward, Caroline and van Dijk, Ko Willems and Ko, Kyvik and Hercberg, Serge and AnteroKesaniemi, Y. and Heath, Simon C. and Herder, Christian and Gm, Lathrop and Hicks, Andrew Aa and Da, Lawlor and Hofman, Albert and Hillman, David R. and Mägi, Reedik and Hui, Jennie and Hingorani, Aroon D. and Bacquer, Olivier Le and Wild, Sarah H. and Witteman, Jaqueline C. M. and Hung, Joe and Ak, Manning and Yarnell, John W. G. and Mt, Martínez Larrad and Isomaa, Bo and Jørgensen, Torben and Jb, McAteer and Jula, Antti and Zillikens, Mc Carola and Zhao, Jing Hua and Kaakinen, Marika and Johnson, Paul R. V. and Lj, McCulloch and Kaprio, Jaakko and Kivimaki, Mika and Bd, Mitchell and Williams, Gordon H. and Knight, Beatrice and Kesaniemi, Ya Antero and Koskinen, Seppo and Ma, Morken and Kovacs, Peter and Mj, Neville and Kyvik, Kirsten Ohm and Ba, Oostra and Marco,  and Le Bacquer, Olivier and Lathrop, Gm Mark and Lecoeur, Cecile and Cn, Palmer and Li, Yun and Lawlor, Debbie A. and Lyssenko, Valeriya and Ys, Aulchenko and Mahley, Robert and Jf, Peden and Mangino, Massimo and APalmer, C. N. and Manning, Alisa K. and Nl, Pedersen and Martínez-Larrad, María Teresa and Af, Pfeiffer and Wichmann, He Erich and McPherson, Ruth and McAteer, Jarred B. and Meisinger, Christa and Wright, Alan F. and Sc, Potter and McCulloch, Laura J. and Melzer, David and Ma, Province and Wilson, James F. and Meyre, David and Bm, Psaty and Mukherjee, Sutapa and Mitchell, Braxton D. and Naitza, Silvia and Morken, Mario A. and Nw, Rayner and Sijbrands, Erik J. G. and Narisu, Narisu and Neville, Matthew J. and Orru, Marco and Aa, Sayer and Pakyz, Ruth and Oostra, Ben A. and Paolisso, Giuseppe and Lj, Scott and Sigurethsson, Gunnar and Pattaro, Cristian and Palmer, Colin N. A. and O’Connell, Jeffrey and Pearson, Daniel and Sj, Sharp and Ej, Sijbrands and Peden, John F. and Perola, Markus and Pedersen, Nancy L. and Pichler, Irene and Polasek, Ozren and Pfeiffer, Andreas F. H. and Sigursson, G. and Nl, Smith and Posthuma, Danielle and Boettcher, Yvonne and Willemsen, Gonneke and Magi, Reedik and Pouta, Anneli and Potter, Simon C. and Ac, Syvänen and Zeggini, Eleftheria and Rathmann, Wolfgang and Province, Michael A. and Zelenika, Diana and -ChristineSyvänen, A. and Psaty, Bruce M. and Ag, Uitterlinden and Zhai, Guangju and Rice, Kenneth and Ripatti, Samuli and Kw, van Dijk and Rivadeneira, Fernando and Gunnar,  and Rayner, Nigel W. and Roden, Michael and Rolandsson, Olov and Syv&amp;auml;nen, Ann-Christine and Sandbaek, Annelli and Pj, Wagner and Sandhu, Manjinder and Van Dijk, K. W. and Sanna, Serena and Hoek, M. and Scheet, Paul and Gb, Walters and Sayer, Avan Aihie and Seedorf, Udo and Kl, Ward and Scott, Laura J. and Shields, Beverley and Mn, Weedon and Sharp, Stephen J. and Sh, Wild and Silveira, Angela and Anke,  and Simpson, Laila and BragiWalters, G. and Singleton, Andrew and Jc, Witteman and Sigurðsson, Gunnar and Jw, Yarnell and Böttcher, Yvonne and Sovio, Ulla and Swift, Amy and Smith, Nicholas L. and Syddall, Holly and Jh, Zhao and Bragi Walters, G. and Tanaka, Toshiko and MWitteman, J. C. and Thorand, Barbara and GYarnell, J. W. and Mc, Zillikens and Tichet, Jean and Tönjes, Anke and Ib, Borecki and Syvanen, Ann-Christine and Rj, Loos and Tuomi, Tiinamaija and Jorgensen, Torben and Consortium, Global BPgen and Pk, Magnusson and Dm, Nathan and Varma, Dhiraj and Uitterlinden, Andre G. and Carola Zillikens, M. and Gh, Williams and At, Hattersley and Visvikis-Siest, Sophie and Vitart, Veronique and Diagram, Consortium and Giant, Consortium and Vogelzangs, Nicole and Gd, Smith and Waeber, Gerard and Sr, Bornstein and Ar, Shuldiner and Walley, Andrew and Gv, Dedoussis and Ad, Morris and Wagner, Peter J. and Watkins, Hugh and Ward, Kim L. and Lj, Palmer and Walters, Gb Bragi and Fb, Hu and Weedon, Michael N. and Pw, Franks and Wh, Kao and Linda Kao, W. H. and Js, Pankow and Mj, Sampson and Pedersen, Oluf and Borecki, Ingrid B. and Meneton, Pierre and Pp, Pramstaller and Loos, Ruth J. F. and He, Wichmann and Af, Wright and Magnusson, Patrik K. E. and Nathan, David M. and Silander, Kaisa and Jf, Wilson and Bergman, Richard N. and Salomaa, Veikko and Hattersley, Andrew T. and Buchanan, Thomas A. and Rn, Bergman and Schwarz, Peter and Collins, Francis S. and Spranger, Joachim and Ta, Buchanan and Bornstein, Stefan R. and Smith, George Davey and Mohlke, Karen L. and Fs, Collins and Karpe, Fredrik and Palmer, Lyle J. and Kl, Mohlke and Tt, Valle and Cooper, Cyrus and Valle, Timo Tt and Shuldiner, Alan R. and Serrano-Ríos, Manuel and Magic, Investigators and Ji, Rotter and Dedoussis, George V. and Lind, Lars and Erich Wichmann, H. and Morris, Andrew D. and Ds, Siscovick and Consortium, Anders Hamsten on behalf of Procardis and Tuomilehto, Jaakko and Ebrahim, Shah and Bw, Penninx and Rotter, Jerome I. and Hu, Frank B. and Altshuler, David and Marmot, Michael and Franks, Paul W. and Siscovick, David S. and Penninx, Brenda W. J. H. and Di, Boomsma and Boomsma, Dorret I. and Manuel,  and Td, Spector and Kuusisto, Johanna and Kao, Wh H. Linda and Laakso, Markku and Spector, Timothy D. and Pankow, James S. and Deloukas, Panos and Davey Smith, George and Hansen, Torben and Tm, Frayling and Frayling, Timothy M. and Sampson, Michael J. and Ferrucci, Luigi and Kong, Augustine and Thorsteinsdottir, Unnur and Stefansson, Kari and Van Duijn, C. M. and Cm, van Duijn and Illig, Thomas and Aulchenko, Yurii S. and Cao, Antonio and Scuteri, Angelo and Rudan, Igor and Jarvelin, Marjo-Riitta and Schlessinger, David and Pramstaller, Peter Paul and Mr, Jarvelin and Uda, Manuela and Stumvoll, Michael and Ruokonen, Aimo and Hamsten, Anders and Campbell, Harry and -RiittaJarvelin, M. and Dm, Waterworth and Waterworth, Dawn M. and Vollenweider, Peter and Peltonen, Leena and Gr, Abecasis and Mooser, Vincent and Abecasis, Gonçalo R. and Wareham, Nicholas J. and Nj, Wareham and Sladek, Robert and Rm, Watanabe and Froguel, Philippe and Watanabe, Richard M. and Jb, Meigs and Consortiu, Anders Hamsten Procardis and Meigs, James B. and Groop, Leif and Boehnke, Michael and Mi, McCarthy and McCarthy, Mark I. and Anders Hamsten Procardis Consortiu, Global BPgen Consortium GIANT Consortium DIAGRAM Consortium MAGIC Investigators and Florez, Jose C. and Jc, Florez and Barroso, Inês and , },
  doi = {10.1038/ng.520},
  month = {jan},
  title = {New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk},
  url = {http://www.nature.com/articles/ng.520.pdf},
  year = {2010}
}

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Journal article published in 2010 by Yvonne, Mandy van Hoek, Cornelia M. van Duijn, Josee Dupuis, Claudia Langenberg, Inga Prokopenko

, Anne U. Jackson, Richa Saxena, Nicole L. Glazer, Maria Teresa Martinez-Larrad, Reedik Mägi, Anna L. Gloyn, Toby Johnson, Cecilia M. Lindgren, Reedik M&auml;gi and other authors. Yvonne, Mandy van Hoek, Cornelia M. van Duijn, Josee Dupuis, Claudia Langenberg, Inga Prokopenko

, Anne U. Jackson, Richa Saxena, Nicole L. Glazer, Maria Teresa Martinez-Larrad, Reedik Mägi, Anna L. Gloyn, Toby Johnson, Cecilia M. Lindgren, Reedik M&auml;gi, Nicole Soranzo, Andrew P. Morris, Hottenga Jj, Gunnar Sigurosson, Paul Elliott, Eleanor Wheeler, Franklin Cs, Thomas, Harald Grallert, Abbas Dehghan

, Perry Jr, Egan Jm, Christine, Nabila Bouatia-Naji, J. JanHottenga, Anke Tönjes, Pau Navarro, Christopher S. Franklin, Kijoung Song, Voight Bf, Jouke Jan Hottenga, Anuj Goel, Stringham Hm, Jeffrey, Taina Lajunen, John R. B. Perry, Niels Grarup

, Josephine M. Egan, Carina Zabena, Jackson Au, Thomas Sparsø, Alex S. F. Doney, Chen Yd, Timpson Nj, Benjamin F. Voight, Man Li, Joshua Randall, Stavroula Kanoni, Heather M. Stringham, Peter Shrader, Christine Cavalcanti-Proença, McCarroll Sa, Meena Kumari, Roccasecca Rm, Lu Qi, Christian Gieger

, Glazer Nl, Nicholas J. Timpson

, Ghislain Rocheleau, Eco J. C. de Geus, Denis Rybin, Erik Ingelsson, Ping An, Beilby Jp, Jeffrey O'Connell, Gudmar Thorleifsson, Bennett Aj, Jian’an Luan, Amanda Elliott, Steven A. McCarroll, Felicity Payne, Valgerdur Steinthorsdottir, Bonnycastle Ll, François Pattou, Rosa Maria Roccasecca, Peter Henneman, Praveen Sethupathy, Morris Ap, Gloyn Al, Kristin Ardlie, Kesaniemi Ya, Yavuz Ariyurek, Bumpstead Sj, Beverley Balkau, Philip Barter, Coin Lj, John P. Beilby, Rafn Benediktsson, Yoav Ben-Shlomo, Lindgren Cm, Cooper Mn, Amanda J. Bennett, Sven Bergmann, Murielle Bochud, Day In, Eric Boerwinkle, Y. Der IdaChen, Amélie Bonnefond

, de Geus Ej, L. J. McOin, Knut Borch-Johnsen, Lori Ll Bonnycastle, Yvonne Böttcher, Erdos Mr, Eric Brunner, Fedson Ac, Torben, Guillaume Charpentier, Suzannah J. Bumpstead, Yii-Der Ida Chen, Forouhi Ng, Peter Chines, E. J. C. De Geus, Robert Clarke, Fox Cs, Lachlan J. M. Coin, Marilyn Cornelis, Franzosi Mg, Matthew N. Cooper, Gabe Crawford, Y. Antero Kesaniemi, Goodarzi Mo, Laura Crisponi, Groves Cj, Jerome Delplanque, M. GraziaFranzosi, Ian N. M. Day, Christian Dina, Michael R. Erdos, Antje Fischer-Rosinsky, Hartikainen Al, Annette C. Fedson, Nita G. Forouhi, G. Mark Lathrop, Heath Sc, Rune Frants, Caroline S. Fox, Pilar Galan, Maria Grazia Franzosi, A. -LiisaHartikainen, Hicks Aa, Jürgen Graessler, Mark O. Goodarzi, Hillman Dr, Scott Grundy, Rhian Gwilliam, Christopher J. Groves, Hingorani Ad, Ulf Gyllensten, Samy Hadjadj, Johnson Pr, Göran Hallmans, Naomi Hammond, Bj Zethelius, Xijing Han, Anna-Liisa Hartikainen, Neelam Hassanali, Caroline Hayward, Ko Willems van Dijk

, Kyvik Ko, Serge Hercberg, Y. AnteroKesaniemi, Simon C. Heath, Christian Herder, Lathrop Gm, Andrew Aa Hicks, Lawlor Da, Albert Hofman, David R. Hillman, Reedik Mägi, Jennie Hui, Aroon D. Hingorani, Olivier Le Bacquer, Sarah H. Wild, Jaqueline C. M. Witteman, Joe Hung, Manning Ak, John W. G. Yarnell, Martínez Larrad Mt, Bo Isomaa, Torben Jørgensen, McAteer Jb, Antti Jula, Mc Carola Zillikens, Jing Hua Zhao, Marika Kaakinen

, Paul R. V. Johnson, McCulloch Lj, Jaakko Kaprio, Mika Kivimaki

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Abstract

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes. ; Josée Dupuis . Lyle J Palmer . et al.

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Abstract