Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

d’Adamo, Adamo Pio; d'Adamo, Ap; van Rijn, M. J.; de Boer, I. H.; de Andrade, M.; Zweiker, R.; van der Harst, P.; de Silva, R.; Wain, Louise V.; de Jong, P. E.; Verwoert, Germaine C.; William Musk, A.; Wild, Sarah H.; Shi, Gang; Johnson, Toby; Smith, Nicholas L.; Wouter Jukema, J.; Voelker, Uwe; Voelzke, Henry; Sober, Siim; Van der Klauw, Melanie M.; Rice, Kenneth M.; Rice, K. M.; Wild, S. H.; Smith, N. L.; Wilkinson, I. B.; Smith, Albert V.; Yasmin,; Sigurdsson, S.; Vita, J. A.; Sie,; Sutton-Tyrrell, K. C.; Shuldiner, A. R.; O'Reilly, Pf F.; Tarasov, K.; Syvannen, A. C.; Wallace, C.; Van Bortel, Lucas; Thompson,; Ziegler, A.; Wells, G. A.; Stewart, A. F.; Sidney, S.; Tang, H.; Mooser, Vincent; Zeller, T.; Wild, P.; Sinning, C.; Tiret, L.; Siscovick, David S.; Volcik, K.; Whitteman, J.; Thorgeirsson, G.; Stark, K.; Wagner, A. K.; Lv, Wain; Bochud, Murielle; Willenborg, C.; Zhao, Jing Hua; Winkelmann, B. R.; Stojakovic, T.; Jh, Zhao; Tomaschitz, A.; Winkler, K.; Wilensky, R.; Waksman, R.; Henneman, Peter; Pf, O'Reilly; Waterworth, D. M.; Walker, M. C.; Wright, B. J.; Yang, Y. A.; Stricker, B. H.; Amin, Najaf; Willerson, J. T.; Pistis, Giorgio; Yang, Q.; Teumer, A.; Luan, Jian’an; Tönjes, A.; Struchalin, M.; Zillikens, M. C.; Hadley, David; Turner, S. T.; Lucas, Gavin; Wild, P. S.; Dörr, Marcus; Wilde, S.; Pirastu, Nicola; Zgaga, L.; Webster, Rebecca J.; Zemunik, T.; Zaboli, G.; Pichler, Irene; Au, Jackson; Aspelund, Thor; Stumvoll, M.; Wang, W.; Rj, Webster; Esko, Tõnu; Shlipak, M. G.; Johnson, Andrew D.; Zhang, Feng; Watzinger, N.; Stritzke, J.; Peden, John F.; Werdan, K.; Jf, Peden; Wass, M. N.; Heath, Simon; Sjögren, M.; Tanaka, Toshiko; Schmidt, Helena; Smit, J. H.; Stenvinkel, P.; Laan, Maris; Sternberg, M. J.; Swaminathan, R.; Ehret, Georg B.; Ubink-Veltmaat, L. J.; Fu, Jingyuan; Waterworth, D.; Zerres, K.; O'reilly, P. F.; Polašek, O.; Milaneschi, Yuri; McArdle, W. L.; Arora, Pankaj; O'donnell, C. J.; Vitart, Veronique; Jj, Hottenga; O’reilly, Paul F.; Pola?ek, O.; Di, Chasman; McArdle, Wendy L.; Trompet, Stella; Li, X.; Bis, Joshua C.; O’donnell, Christopher J.; Jl, Bragg Gresham; Mitchell, G. F.; Janssens, Ac Cecile Jw W.; McEniery, C. M.; Bz, Alizadeh; O'shaughnessy, K. M.; Newhouse, S. J.; Lopez, Lorna M.; Jc, Chambers; Lehtimäki, Terho; Schut, A. F.; Newman,; Campbell, Harry; O'Donnell, Cj J.; Nelson, Christopher P.; Liu, Y.; Uitterlinden, Andre G.; Igl, Wilmar; Launer, Lenore J.; Morrison, Alanna C.; Parsa, A.; McArdle, P. F.; Polasek, Ozren; Larson, Martin G.; Lm, Lopez; Post, W. S.; Scuteri, A.; Sanna, S.; Rietzschel, Ernst R.; Linsel-Nitschke, P.; Cp, Nelson; Pihur, Vasyl; Lloyd-Jones, H.; Jackson, Anne U.; Mattace-Raso, Francesco Us S.; Lugauer, I.; Sijbrands, Eric Jg G.; Ac, Morrison; Lundmark, P.; Maouche, S.; Moore, J. S.; Muir, D.; Sk, Ganesh; Murray, E.; Segers, Patrick; Vasan, Ramachandran S.; Rivadeneira, Fernando; Neudert, J.; Guo, Xiuqing; Niblett, D.; Wang, Thomas J.; O'leary, K.; Fu, Mattace Raso; Kühnel, Brigitte; Ouwehand, W. H.; Mg, Larson; Pollard, H.; Hottenga, Jouke-Jan; Rankin, A.; Ej, Sijbrands; Rice, C. M.; Boban, Mladen; Chasman, Daniel I.; Sager, H.; Ag, Uitterlinden; Vollenweider, Peter; Sambrook, J.; Schmitz, G.; Sj, Hwang; Bragg-Gresham, Jennifer L.; Scholz, M.; Waeber, Gerard; Schroeder, L.; Alizadeh, Behrooz Z.; Rs, Vasan; Schunkert, H.; Gc, Verwoert; Chambers, John C.; Hofman, Albert; Li, Xinzhong; Tj, Wang; Pouta, Anneli; de Geus, Eco Jc C.; Zitting, Paavo; Reilly,; Kundu, Suman; Taylor, Kent D.; McPherson, R.; Li, M.; Musunuru, K.; Ad, Johnson; Völker, Uwe; Schillert, A.; Van Der Klauw, M. M.; Roberts, R.; Völzke, Henry; van der Klauw, Melanie Mm; Wl, McArdle; Study, LifeLines Cohort; Myers, R.; Tammesoo, Mari-Liis; Quertermous, T.; Hk, Kroemer; Risch, N.; Schnabel, R.; Ganesh, Santhi K.; Nicaud,; Rupprecht, H. J.; Bergmann, Sven; Perret, C.; Nl, Glazer; Proust, C.; Münzel, T.; Kd, Taylor; Lumley, T.; Marciante, K.; Tb, Harris; Laitinen, Jaana; O' Donnell, C. J.; Rice, K.; Rotter, J. I.; Hwang, Shih-Jen; Ramachandran,; Km, Rice; Lieb, W.; Schreiber, S.; Ml, Tammesoo; Nolte, Ilja M.; Van Dijk, K. W.; Mitchell, Gary F.; Lathrop, Mark; Loley, C.; Penninx, Brenda W.; Medack, A.; Meisinger, C.; Nahrstedt, J.; Org, Elin; Kt, Khaw; Sõber, Siim; Peters, A.; Alavere, Helene; Lu, Xiaowen; Voight, Benjamin F.; Haller, Toomas; März, W.; Meinitzer, A.; Keis, Aime; Pilz, S.; Kroemer, Heyo K.; Renner, W.; Scharnagl, H.; Peltonen, L.; Van Duijn, C. M.; Aulchenko, Yurii; Schwartz, S. M.; Qu, L.; Masciullo, Corrado; Glazer, Nicole L.; Barroso, Inês S.; Im, Nolte; Matthai, W.; Pichard, A. D.; Harris, Tamara B.; Sala, Cinzia; Bw, Penninx; Av, Smith; Galan, Pilar; Satler, L.; Lindsay, J. M.; Rader, D. J.; Hercberg, Serge; Melander, Olle; Loehr, L. R.; Rosamond, W. D.; Gb, Ehret; Salomaa, Veikko; Eyheramendy, Susana; Murabito, J.; Pattaro, C.; Olden, M.; Bf, Voight; O'connell,; Paré, G.; Lohman, K.; Khaw, Kay-Tee; Ulivi, Sheila; Cj, O'Donnell; Probst-Hensch, N. M.; Rampersaud, E.; Musk, Aw William; Mitchell, B. D.; Metter, J.; Shin, So-Youn; Corre, Tanguy; Province, M.; Schnabel, R. B.; Munzel, T. F.; Groop, Leif; Leak, T. S.; Minelli, C.; Nitsch, D.; Mägi, R.; Fs, Collins; Nauck, M.; van Dijk, Ko Willems; Mangino, Massimo; Rochat, T.; Mm, van der Klauw; Rn, Bergman; Paulweber, B.; Prokopenko, I.; Soranzo, Nicole; Fabretto, Antonella; Jp, Beilby; Pramstaller, P. P.; Lind, L.; Faletra, Flavio; Watkins, Hugh; Najjar, Samer Ss; Rodeheffer, R. J.; Aw, Musk; LifeLines Cohort Study, The; Reffelmann, T.; Redfield, M. M.; Facheris, Maurizio; Lord, G. M.; Sy, Shin; Loitfelder, Marisa; Zeginigg, Marion; Lawlor, D. A.; Jc, Bis; Sehmi, J. S.; van Duijn, Cornelia M.; Li, Y.; Luttropp, K.; Maréchal, C.; Del Greco, Fabiola M.; Hung, Joseph; Parker, Alex N.; Nordfors, L.; Perucha, E.; Collins, Francis S.; Roderick, P. J.; Navarro, Pau; Ruokonen, A.; Rose, Lynda M.; Schalling, M.; Bergman, Richard N.; Schlessinger, D.; Schlieper, G.; Beilby, John P.; Singleton, Andrew; Seelen,; Maxwell, P. H.; McCarthy, M. I.; Lightstone, L.; Goel, Anuj; Navis, G.; Willemsen, Gonneke; Ss, Najjar; Hamsten, Anders; Ac, Janssens; Sh, Wild; Am, Corsi; Gider, Pierre; Doerr, Marcus; Cecile J. W. Janssens, A.; Stott, David J.; Hernandez, Dena; Hotteng, Jouke-Jan; Ej, de Geus; Kuehnel, Brigitte; Orru, Marco; Uda, Manuela; An, Parker; Chen, Y. D.; Del Greco, M. Fabiola; Lm, Rose; Fabiola Del Greco, M.; Zhang, Weihua; Cockcroft,; Eiriksdottir, G.; Starr, John M.; Benjamin, E. J.; Scott, James; Corsi, Anna Maria; Hamburg, N. M.; Isaacs, A.; Herrington, D. M.; Andrews, J. S.; Ding, J.; Howard, T. D.; Gibson, Q.; Buckley, Brendan; Dehghan, A.; Lakatta, E. G.; Viikari, Jorma; Lindeman, Jan H.; Jewell, E.; Yd, Chen; Attwood, T.; Belz, S.; Gl, Burke; Chen, Yii-Der Ida; Meitinger, Thomas; Braund, P.; Cambien, F.; Cooper, J.; D'adamo, Adamo Pio; Crisp-Hihn, A.; Deloukas, P.; Foad, N.; Eardman, J.; Goodall, A. H.; Plump, Andrew; Gracey, J.; Gray, E.; Jm, Starr; Gulde, S.; Gwilliams, R.; Kähönen, Mika; Heimerl, S.; De Bacquer, Dirk; Hengstenberg, C.; Jh, Lindeman; Jolley, J.; Döring, Angela; Burke, Gregory L.; Krishnan, U.; Pa, Hoen; Samani, Nilesh J.; De Backer, Gui G.; Ongen, Halit; De Buyzere, Marc L.; Ir, König; Davies, Gail; Consortium, EchoGen; Bekaert, Sofie; Wichmann, He-Erich; Emilsson, Valur; Gillebert, Thierry C.; Jf, Felix; De Meyer, Tim; Kathiresan, S.; Jc, Hopewell; Assimes, T. L.; Hall, A.; Raitakari, Olli T.; Laaksonen, R.; Absher, D.; Stefansson, Kari; Chen, L.; König, Ir R.; Stolk, Ronald P.; Cupples, L. A.; Thorleifsson, Gudmar; Halperin, E.; Thorsteinsdottir, Unnur; Al, Destefano; Clarke, Robert; Wright, Alan F.; Assime, T. L.; Chen, Y.-D. I.; De Geus, E. J. C.; Fortmann, S.; Consortium, AortaGen; Felix, Janine F.; Go, A.; Hlatky, M.; Iribarren, C.; Breteler, Monique; Gf, Mitchell; Wilson, James F.; Preuss, Michael; Knowles, J.; Hopewell, Jemma C.; Destefano, Al L.; Debette, Stéphanie; Rudan, Igor; Blankenberg, S.; Nl, Smith; Lackner, K.; Spector, Tim D.; Consortium, KidneyGen; Bickel, C.; Fornage, Myriam; Barbalic, M.; Chen, I. Y.; Cupples, L.; Palmer, Lyle J.; Palmas, Walter; Demissie-Banjaw, S.; Folsom, A.; Heckbert, S.; Holm, Hilma; Hoen, Peter A. C. 'T T.; Consortium, CKDGen; Consortium, Cardiogenics; König, Inke R.; Gretarsdottir, S.; Gulcher,; Kong, A.; Andersen, K.; Loos, Ruth Jf F.; Nj, Samani; Fischer, M.; Grosshennig, A.; DeStefano, Anita L.; Aherrahrou, Z.; CKDGen Consortium, The; Bruse, P.; Doering, Angela; Illig, T.; Klopp, N.; Wareham, Nicholas J.; Böhm, B. O.; Hayward, Caroline; Schmidt, Reinhold; Dobnig, H.; Ij, Deary; Deary, Ian J.; Grammer, T. B.; Hoffmann, M. M.; Gyllensten, Ulf B.; He, Wichmann; Oostra, Ben A.; Kleber, M.; Cardiogenics Consortium, The; 't Hoen, Peter Ac C.; Ot, Raitakari; Guiducci, C.; Tuomilehto, Jaakko; Burtt, N.; Strachan, David P.; Gabriel, S. B.; Elosua, R.; Kooner, Jaspal S.; Pfeufer, Arne; Js, Kooner; Dandona, S.; Witteman, Jacqueline Cm M.; Jarinova, O.; Siscovick, David; Rp, Stolk; Jukema, Jw Wouter; Dörr, Marcus; Jw, Jukema; Hakonarson, H. H.; Devaney, J.; Af, Wright; Boomsma, Dorret I.; Burnett,; Toniolo, Daniela; Kent, K. M.; Di, Boomsma; Bandinelli, Stefania; Knouff, C. W.; Snieder, Harold; Kahonen, Mika; Epstein, S. E.; Ridker, Paul M.; Braund, P. S.; Balmforth, A. J.; Ub, Gyllensten; Ball, S. G.; Hall, A. S.; Meneton, Pierre; Ferrucci, Luigi; Jf, Wilson; Demissie, S.; Aulchenko, Yurii S.; Folsom, A. R.; Benjamin, E.; Farrall, Martin; Haritunians, T.; Couper, D.; Gottdiener, J. S.; Chang, P. P.; Heckbert,; Metspalu, Andres; Td, Spector; Fox, E. R.; Charge, Consortium Heart Failure Working Group; Launer, Lenore; Köttgen, A.; Munroe, Patricia B.; Koenig, Inke R.; Lj, Palmer; Rettig, Rainer; Böger, C. A.; Psaty, Bruce M.; Fuchsberger, C.; Tobin, Martin D.; Gao, X.; Gasparini, Paolo; C 't Hoen, Peter A.; Ketkar, S.; Beckmann, Jacques S.; Atkinson, E. J.; Cornelis, M. C.; Rao, Dabeeru C.; Kronenberg, F.; Altshuler, David; Arking, D. E.; Cavalieri, M.; Koenig, W.; Giallauria, F.; Feitosa, M.; Rj, Loos; Kolcic, I.; CardioGram, The; Hu, F. B.; Johansson, A.; Gieger, Christian; Ellinghaus, D.; Imboden, M.; Brandstätter, A.; Kollerits, B.; Kedenko, L.; Kovacs, P.; Campbell, S.; Endlich, K.; Badola, S.; Nj, Wareham; Erich Wichmann, H.; Kardia, S. L.; Ba, Oostra; Curhan, G. C.; Franke, A.; Coresh, J.; Borecki, I.; Krämer, B. K.; Hastie, N.; Newton-Cheh, Christopher; Kao, W. H.; Heid, I. M.; Fox, C. S.; Felix, S. B.; Levy, Daniel; Dp, Strachan; Homuth, G.; Aragam, J.; Js, Beckmann; Greiser, K. H.; Erdmann, Jeanette; Deckers, J. W.; Jc, Witteman; Lackner, K. J.; Ingelsson, E.; Boerwinkle, Eric; Kullo, I.; Haerting, J.; Arnett, D. K.; EchoGen Consortium, The; Boehnke, Michael; Jarvelin, Marjo-Riitta; Blettner, M.; Friedrich, N.; Gale, D. P.; AortaGen Consortium, The; Pm, Ridker; Ahmadi, K. R.; Abecasis, Gonçalo R.; Bakker, S. J.; Chakravarti, Aravinda; Kw, van Dijk; Bilo, H. J.; Mr, Jarvelin; Brown, M. J.; Connell, J. M.; Cook, H. T.; Cotlarciuc, I.; Gudnason, Vilmundur; Davey Smith, G.; Deng, G.; Gr, Abecasis; Devuyst, O.; Dikkeschei, L. D.; Dimkovic, N.; Dockrell, M.; Dominiczak, A.; Ebrahim, S.; Eggermann, T.; Floege, J.; Caulfield, Mark J.; Pb, Munroe; Forouhi, N. G.; Gansevoort, R. T.; Bm, Psaty; Han, X.; Hedblad, B.; Homan van der Heide, J. J.; Mj, Caulfield; Hepkema, B. G.; Hernandez-Fuentes, M.; Hypponen, E.; Dc, Rao; Kleefstra, N.; Elliott, Paul; Lagou,; Lapsley, M.; Md, Tobin; Charge Consortium Heart Failure, The; KidneyGen Consortium, The; ,; Cm, van Duijn

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Louise Wain
d’Adamo et al., 2011

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@article{d’Adamo2011,
  abstract = {Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.},
  author = {d’Adamo, Adamo Pio and d'Adamo, Ap and van Rijn, M. J. and de Boer, I. H. and de Andrade, M. and Zweiker, R. and van der Harst, P. and de Silva, R. and Wain, Louise V. and de Jong, P. E. and Verwoert, Germaine C. and William Musk, A. and Wild, Sarah H. and Shi, Gang and Johnson, Toby and Smith, Nicholas L. and Wouter Jukema, J. and Voelker, Uwe and Voelzke, Henry and Sober, Siim and Van der Klauw, Melanie M. and Rice, Kenneth M. and Rice, K. M. and Wild, S. H. and Smith, N. L. and Wilkinson, I. B. and Smith, Albert V. and Yasmin,  and Sigurdsson, S. and Vita, J. A. and Sie,  and Sutton-Tyrrell, K. C. and Shuldiner, A. R. and O'Reilly, Pf F. and Tarasov, K. and Syvannen, A. C. and Wallace, C. and Van Bortel, Lucas and Thompson,  and Ziegler, A. and Wells, G. A. and Stewart, A. F. and Sidney, S. and Tang, H. and Mooser, Vincent and Zeller, T. and Wild, P. and Sinning, C. and Tiret, L. and Siscovick, David S. and Volcik, K. and Whitteman, J. and Thorgeirsson, G. and Stark, K. and Wagner, A. K. and Lv, Wain and Bochud, Murielle and Willenborg, C. and Zhao, Jing Hua and Winkelmann, B. R. and Stojakovic, T. and Jh, Zhao and Tomaschitz, A. and Winkler, K. and Wilensky, R. and Waksman, R. and Henneman, Peter and Pf, O'Reilly and Waterworth, D. M. and Walker, M. C. and Wright, B. J. and Yang, Y. A. and Stricker, B. H. and Amin, Najaf and Willerson, J. T. and Pistis, Giorgio and Yang, Q. and Teumer, A. and Luan, Jian’an and Tönjes, A. and Struchalin, M. and Zillikens, M. C. and Hadley, David and Turner, S. T. and Lucas, Gavin and Wild, P. S. and Dörr, Marcus and Wilde, S. and Pirastu, Nicola and Zgaga, L. and Webster, Rebecca J. and Zemunik, T. and Zaboli, G. and Pichler, Irene and Au, Jackson and Aspelund, Thor and Stumvoll, M. and Wang, W. and Rj, Webster and Esko, Tõnu and Shlipak, M. G. and Johnson, Andrew D. and Zhang, Feng and Watzinger, N. and Stritzke, J. and Peden, John F. and Werdan, K. and Jf, Peden and Wass, M. N. and Heath, Simon and Sjögren, M. and Tanaka, Toshiko and Schmidt, Helena and Smit, J. H. and Stenvinkel, P. and Laan, Maris and Sternberg, M. J. and Swaminathan, R. and Ehret, Georg B. and Ubink-Veltmaat, L. J. and Fu, Jingyuan and Waterworth, D. and Zerres, K. and O'reilly, P. F. and Polašek, O. and Milaneschi, Yuri and McArdle, W. L. and Arora, Pankaj and O'donnell, C. J. and Vitart, Veronique and Jj, Hottenga and O’reilly, Paul F. and Pola?ek, O. and Di, Chasman and McArdle, Wendy L. and Trompet, Stella and Li, X. and Bis, Joshua C. and O’donnell, Christopher J. and Jl, Bragg Gresham and Mitchell, G. F. and Janssens, Ac Cecile Jw W. and McEniery, C. M. and Bz, Alizadeh and O'shaughnessy, K. M. and Newhouse, S. J. and Lopez, Lorna M. and Jc, Chambers and Lehtimäki, Terho and Schut, A. F. and Newman,  and Campbell, Harry and O'Donnell, Cj J. and Nelson, Christopher P. and Liu, Y. and Uitterlinden, Andre G. and Igl, Wilmar and Launer, Lenore J. and Morrison, Alanna C. and Parsa, A. and McArdle, P. F. and Polasek, Ozren and Larson, Martin G. and Lm, Lopez and Post, W. S. and Scuteri, A. and Sanna, S. and Rietzschel, Ernst R. and Linsel-Nitschke, P. and Cp, Nelson and Pihur, Vasyl and Lloyd-Jones, H. and Jackson, Anne U. and Mattace-Raso, Francesco Us S. and Lugauer, I. and Sijbrands, Eric Jg G. and Ac, Morrison and Lundmark, P. and Maouche, S. and Moore, J. S. and Muir, D. and Sk, Ganesh and Murray, E. and Segers, Patrick and Vasan, Ramachandran S. and Rivadeneira, Fernando and Neudert, J. and Guo, Xiuqing and Niblett, D. and Wang, Thomas J. and O'leary, K. and Fu, Mattace Raso and Kühnel, Brigitte and Ouwehand, W. H. and Mg, Larson and Pollard, H. and Hottenga, Jouke-Jan and Rankin, A. and Ej, Sijbrands and Rice, C. M. and Boban, Mladen and Chasman, Daniel I. and Sager, H. and Ag, Uitterlinden and Vollenweider, Peter and Sambrook, J. and Schmitz, G. and Sj, Hwang and Bragg-Gresham, Jennifer L. and Scholz, M. and Waeber, Gerard and Schroeder, L. and Alizadeh, Behrooz Z. and Rs, Vasan and Schunkert, H. and Gc, Verwoert and Chambers, John C. and Hofman, Albert and Li, Xinzhong and Tj, Wang and Pouta, Anneli and de Geus, Eco Jc C. and Zitting, Paavo and Reilly,  and Kundu, Suman and Taylor, Kent D. and McPherson, R. and Li, M. and Musunuru, K. and Ad, Johnson and Völker, Uwe and Schillert, A. and Van Der Klauw, M. M. and Roberts, R. and Völzke, Henry and van der Klauw, Melanie Mm and Wl, McArdle and Study, LifeLines Cohort and Myers, R. and Tammesoo, Mari-Liis and Quertermous, T. and Hk, Kroemer and Risch, N. and Schnabel, R. and Ganesh, Santhi K. and Nicaud,  and Rupprecht, H. J. and Bergmann, Sven and Perret, C. and Nl, Glazer and Proust, C. and Münzel, T. and Kd, Taylor and Lumley, T. and Marciante, K. and Tb, Harris and Laitinen, Jaana and O' Donnell, C. J. and Rice, K. and Rotter, J. I. and Hwang, Shih-Jen and Ramachandran,  and Km, Rice and Lieb, W. and Schreiber, S. and Ml, Tammesoo and Nolte, Ilja M. and Van Dijk, K. W. and Mitchell, Gary F. and Lathrop, Mark and Loley, C. and Penninx, Brenda W. and Medack, A. and Meisinger, C. and Nahrstedt, J. and Org, Elin and Kt, Khaw and Sõber, Siim and Peters, A. and Alavere, Helene and Lu, Xiaowen and Voight, Benjamin F. and Haller, Toomas and März, W. and Meinitzer, A. and Keis, Aime and Pilz, S. and Kroemer, Heyo K. and Renner, W. and Scharnagl, H. and Peltonen, L. and Van Duijn, C. M. and Aulchenko, Yurii and Schwartz, S. M. and Qu, L. and Masciullo, Corrado and Glazer, Nicole L. and Barroso, Inês S. and Im, Nolte and Matthai, W. and Pichard, A. D. and Harris, Tamara B. and Sala, Cinzia and Bw, Penninx and Av, Smith and Galan, Pilar and Satler, L. and Lindsay, J. M. and Rader, D. J. and Hercberg, Serge and Melander, Olle and Loehr, L. R. and Rosamond, W. D. and Gb, Ehret and Salomaa, Veikko and Eyheramendy, Susana and Murabito, J. and Pattaro, C. and Olden, M. and Bf, Voight and O'connell,  and Paré, G. and Lohman, K. and Khaw, Kay-Tee and Ulivi, Sheila and Cj, O'Donnell and Probst-Hensch, N. M. and Rampersaud, E. and Musk, Aw William and Mitchell, B. D. and Metter, J. and Shin, So-Youn and Corre, Tanguy and Province, M. and Schnabel, R. B. and Munzel, T. F. and Groop, Leif and Leak, T. S. and Minelli, C. and Nitsch, D. and Mägi, R. and Fs, Collins and Nauck, M. and van Dijk, Ko Willems and Mangino, Massimo and Rochat, T. and Mm, van der Klauw and Rn, Bergman and Paulweber, B. and Prokopenko, I. and Soranzo, Nicole and Fabretto, Antonella and Jp, Beilby and Pramstaller, P. P. and Lind, L. and Faletra, Flavio and Watkins, Hugh and Najjar, Samer Ss and Rodeheffer, R. J. and Aw, Musk and LifeLines Cohort Study, The and Reffelmann, T. and Redfield, M. M. and Facheris, Maurizio and Lord, G. M. and Sy, Shin and Loitfelder, Marisa and Zeginigg, Marion and Lawlor, D. A. and Jc, Bis and Sehmi, J. S. and van Duijn, Cornelia M. and Li, Y. and Luttropp, K. and Maréchal, C. and Del Greco, Fabiola M. and Hung, Joseph and Parker, Alex N. and Nordfors, L. and Perucha, E. and Collins, Francis S. and Roderick, P. J. and Navarro, Pau and Ruokonen, A. and Rose, Lynda M. and Schalling, M. and Bergman, Richard N. and Schlessinger, D. and Schlieper, G. and Beilby, John P. and Singleton, Andrew and Seelen,  and Maxwell, P. H. and McCarthy, M. I. and Lightstone, L. and Goel, Anuj and Navis, G. and Willemsen, Gonneke and Ss, Najjar and Hamsten, Anders and Ac, Janssens and Sh, Wild and Am, Corsi and Gider, Pierre and Doerr, Marcus and Cecile J. W. Janssens, A. and Stott, David J. and Hernandez, Dena and Hotteng, Jouke-Jan and Ej, de Geus and Kuehnel, Brigitte and Orru, Marco and Uda, Manuela and An, Parker and Chen, Y. D. and Del Greco, M. Fabiola and Lm, Rose and Fabiola Del Greco, M. and Zhang, Weihua and Cockcroft,  and Eiriksdottir, G. and Starr, John M. and Benjamin, E. J. and Scott, James and Corsi, Anna Maria and Hamburg, N. M. and Isaacs, A. and Herrington, D. M. and Andrews, J. S. and Ding, J. and Howard, T. D. and Gibson, Q. and Buckley, Brendan and Dehghan, A. and Lakatta, E. G. and Viikari, Jorma and Lindeman, Jan H. and Jewell, E. and Yd, Chen and Attwood, T. and Belz, S. and Gl, Burke and Chen, Yii-Der Ida and Meitinger, Thomas and Braund, P. and Cambien, F. and Cooper, J. and D'adamo, Adamo Pio and Crisp-Hihn, A. and Deloukas, P. and Foad, N. and Eardman, J. and Goodall, A. H. and Plump, Andrew and Gracey, J. and Gray, E. and Jm, Starr and Gulde, S. and Gwilliams, R. and Kähönen, Mika and Heimerl, S. and De Bacquer, Dirk and Hengstenberg, C. and Jh, Lindeman and Jolley, J. and Döring, Angela and Burke, Gregory L. and Krishnan, U. and Pa, Hoen and Samani, Nilesh J. and De Backer, Gui G. and Ongen, Halit and De Buyzere, Marc L. and Ir, König and Davies, Gail and Consortium, EchoGen and Bekaert, Sofie and Wichmann, He-Erich and Emilsson, Valur and Gillebert, Thierry C. and Jf, Felix and De Meyer, Tim and Kathiresan, S. and Jc, Hopewell and Assimes, T. L. and Hall, A. and Raitakari, Olli T. and Laaksonen, R. and Absher, D. and Stefansson, Kari and Chen, L. and König, Ir R. and Stolk, Ronald P. and Cupples, L. A. and Thorleifsson, Gudmar and Halperin, E. and Thorsteinsdottir, Unnur and Al, Destefano and Clarke, Robert and Wright, Alan F. and Assime, T. L. and Chen, Y.-D. I. and De Geus, E. J. C. and Fortmann, S. and Consortium, AortaGen and Felix, Janine F. and Go, A. and Hlatky, M. and Iribarren, C. and Breteler, Monique and Gf, Mitchell and Wilson, James F. and Preuss, Michael and Knowles, J. and Hopewell, Jemma C. and Destefano, Al L. and Debette, Stéphanie and Rudan, Igor and Blankenberg, S. and Nl, Smith and Lackner, K. and Spector, Tim D. and Consortium, KidneyGen and Bickel, C. and Fornage, Myriam and Barbalic, M. and Chen, I. Y. and Cupples, L. and Palmer, Lyle J. and Palmas, Walter and Demissie-Banjaw, S. and Folsom, A. and Heckbert, S. and Holm, Hilma and Hoen, Peter A. C. 'T T. and Consortium, CKDGen and Consortium, Cardiogenics and König, Inke R. and Gretarsdottir, S. and Gulcher,  and Kong, A. and Andersen, K. and Loos, Ruth Jf F. and Nj, Samani and Fischer, M. and Grosshennig, A. and DeStefano, Anita L. and Aherrahrou, Z. and CKDGen Consortium, The and Bruse, P. and Doering, Angela and Illig, T. and Klopp, N. and Wareham, Nicholas J. and Böhm, B. O. and Hayward, Caroline and Schmidt, Reinhold and Dobnig, H. and Ij, Deary and Deary, Ian J. and Grammer, T. B. and Hoffmann, M. M. and Gyllensten, Ulf B. and He, Wichmann and Oostra, Ben A. and Kleber, M. and Cardiogenics Consortium, The and 't Hoen, Peter Ac C. and Ot, Raitakari and Guiducci, C. and Tuomilehto, Jaakko and Burtt, N. and Strachan, David P. and Gabriel, S. B. and Elosua, R. and Kooner, Jaspal S. and Pfeufer, Arne and Js, Kooner and Dandona, S. and Witteman, Jacqueline Cm M. and Jarinova, O. and Siscovick, David and Rp, Stolk and Jukema, Jw Wouter and Dörr, Marcus and Jw, Jukema and Hakonarson, H. H. and Devaney, J. and Af, Wright and Boomsma, Dorret I. and Burnett,  and Toniolo, Daniela and Kent, K. M. and Di, Boomsma and Bandinelli, Stefania and Knouff, C. W. and Snieder, Harold and Kahonen, Mika and Epstein, S. E. and Ridker, Paul M. and Braund, P. S. and Balmforth, A. J. and Ub, Gyllensten and Ball, S. G. and Hall, A. S. and Meneton, Pierre and Ferrucci, Luigi and Jf, Wilson and Demissie, S. and Aulchenko, Yurii S. and Folsom, A. R. and Benjamin, E. and Farrall, Martin and Haritunians, T. and Couper, D. and Gottdiener, J. S. and Chang, P. P. and Heckbert,  and Metspalu, Andres and Td, Spector and Fox, E. R. and Charge, Consortium Heart Failure Working Group and Launer, Lenore and Köttgen, A. and Munroe, Patricia B. and Koenig, Inke R. and Lj, Palmer and Rettig, Rainer and Böger, C. A. and Psaty, Bruce M. and Fuchsberger, C. and Tobin, Martin D. and Gao, X. and Gasparini, Paolo and C 't Hoen, Peter A. and Ketkar, S. and Beckmann, Jacques S. and Atkinson, E. J. and Cornelis, M. C. and Rao, Dabeeru C. and Kronenberg, F. and Altshuler, David and Arking, D. E. and Cavalieri, M. and Koenig, W. and Giallauria, F. and Feitosa, M. and Rj, Loos and Kolcic, I. and CardioGram, The and Hu, F. B. and Johansson, A. and Gieger, Christian and Ellinghaus, D. and Imboden, M. and Brandstätter, A. and Kollerits, B. and Kedenko, L. and Kovacs, P. and Campbell, S. and Endlich, K. and Badola, S. and Nj, Wareham and Erich Wichmann, H. and Kardia, S. L. and Ba, Oostra and Curhan, G. C. and Franke, A. and Coresh, J. and Borecki, I. and Krämer, B. K. and Hastie, N. and Newton-Cheh, Christopher and Kao, W. H. and Heid, I. M. and Fox, C. S. and Felix, S. B. and Levy, Daniel and Dp, Strachan and Homuth, G. and Aragam, J. and Js, Beckmann and Greiser, K. H. and Erdmann, Jeanette and Deckers, J. W. and Jc, Witteman and Lackner, K. J. and Ingelsson, E. and Boerwinkle, Eric and Kullo, I. and Haerting, J. and Arnett, D. K. and EchoGen Consortium, The and Boehnke, Michael and Jarvelin, Marjo-Riitta and Blettner, M. and Friedrich, N. and Gale, D. P. and AortaGen Consortium, The and Pm, Ridker and Ahmadi, K. R. and Abecasis, Gonçalo R. and Bakker, S. J. and Chakravarti, Aravinda and Kw, van Dijk and Bilo, H. J. and Mr, Jarvelin and Brown, M. J. and Connell, J. M. and Cook, H. T. and Cotlarciuc, I. and Gudnason, Vilmundur and Davey Smith, G. and Deng, G. and Gr, Abecasis and Devuyst, O. and Dikkeschei, L. D. and Dimkovic, N. and Dockrell, M. and Dominiczak, A. and Ebrahim, S. and Eggermann, T. and Floege, J. and Caulfield, Mark J. and Pb, Munroe and Forouhi, N. G. and Gansevoort, R. T. and Bm, Psaty and Han, X. and Hedblad, B. and Homan van der Heide, J. J. and Mj, Caulfield and Hepkema, B. G. and Hernandez-Fuentes, M. and Hypponen, E. and Dc, Rao and Kleefstra, N. and Elliott, Paul and Lagou,  and Lapsley, M. and Md, Tobin and Charge Consortium Heart Failure, The and KidneyGen Consortium, The and ,  and Cm, van Duijn},
  doi = {10.1038/ng.922},
  month = {sep},
  title = {Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure},
  url = {http://www.nature.com/articles/ng.922.pdf},
  year = {2011}
}

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Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Journal article published in 2011 by Adamo Pio d’Adamo, Ap d'Adamo, M. J. van Rijn, I. H. de Boer, M. de Andrade, R. Zweiker, P. van der Harst, R. de Silva, Louise V. Wain

, P. E. de Jong, Germaine C. Verwoert, A. William Musk, Sarah H. Wild, Gang Shi, Toby Johnson and other authors. Adamo Pio d’Adamo, Ap d'Adamo, M. J. van Rijn, I. H. de Boer, M. de Andrade, R. Zweiker, P. van der Harst, R. de Silva, Louise V. Wain

, P. E. de Jong, Germaine C. Verwoert, A. William Musk, Sarah H. Wild, Gang Shi, Toby Johnson, Nicholas L. Smith, J. Wouter Jukema, Uwe Voelker, Henry Voelzke, Siim Sober, Melanie M. Van der Klauw, Kenneth M. Rice, K. M. Rice, S. H. Wild, N. L. Smith, I. B. Wilkinson, Albert V. Smith, Yasmin, S. Sigurdsson, J. A. Vita, Sie, K. C. Sutton-Tyrrell, A. R. Shuldiner, Pf F. O'Reilly, K. Tarasov, A. C. Syvannen, C. Wallace, Lucas Van Bortel, Thompson, A. Ziegler, G. A. Wells, A. F. Stewart, S. Sidney, H. Tang, Vincent Mooser, T. Zeller, P. Wild, C. Sinning, L. Tiret, David S. Siscovick, K. Volcik, J. Whitteman, G. Thorgeirsson, K. Stark, A. K. Wagner, Wain Lv, Murielle Bochud, C. Willenborg, Jing Hua Zhao, B. R. Winkelmann, T. Stojakovic, Zhao Jh, A. Tomaschitz, K. Winkler, R. Wilensky, R. Waksman, Peter Henneman, O'Reilly Pf, D. M. Waterworth, M. C. Walker, B. J. Wright, Y. A. Yang, B. H. Stricker, Najaf Amin, J. T. Willerson, Giorgio Pistis, Q. Yang, A. Teumer, Jian’an Luan, A. Tönjes, M. Struchalin, M. C. Zillikens, David Hadley, S. T. Turner, Gavin Lucas, P. S. Wild, Marcus Dörr, S. Wilde, Nicola Pirastu, L. Zgaga, Rebecca J. Webster, T. Zemunik, G. Zaboli, Irene Pichler

, Jackson Au, Thor Aspelund, M. Stumvoll, W. Wang, Webster Rj, Tõnu Esko

, M. G. Shlipak, Andrew D. Johnson, Feng Zhang, N. Watzinger, J. Stritzke, John F. Peden, K. Werdan, Peden Jf, M. N. Wass, Simon Heath, M. Sjögren, Toshiko Tanaka, Helena Schmidt, J. H. Smit, P. Stenvinkel, Maris Laan

, M. J. Sternberg, R. Swaminathan, Georg B. Ehret, L. J. Ubink-Veltmaat, Jingyuan Fu, D. Waterworth, K. Zerres, P. F. O'reilly, O. Polašek, Yuri Milaneschi, W. L. McArdle, Pankaj Arora, C. J. O'donnell, Veronique Vitart, Hottenga Jj, Paul F. O’reilly, O. Pola?ek, Chasman Di, Wendy L. McArdle, Stella Trompet, X. Li, Joshua C. Bis, Christopher J. O’donnell, Bragg Gresham Jl, G. F. Mitchell, Ac Cecile Jw W. Janssens

, C. M. McEniery, Alizadeh Bz, K. M. O'shaughnessy, S. J. Newhouse, Lorna M. Lopez, Chambers Jc, Terho Lehtimäki, A. F. Schut, Newman, Harry Campbell, Cj J. O'Donnell, Christopher P. Nelson, Y. Liu, Andre G. Uitterlinden, Wilmar Igl, Lenore J. Launer, Alanna C. Morrison, A. Parsa, P. F. McArdle, Ozren Polasek, Martin G. Larson

, Lopez Lm, W. S. Post, A. Scuteri, S. Sanna, Ernst R. Rietzschel, P. Linsel-Nitschke, Nelson Cp, Vasyl Pihur, H. Lloyd-Jones, Anne U. Jackson, Francesco Us S. Mattace-Raso, I. Lugauer, Eric Jg G. Sijbrands, Morrison Ac, P. Lundmark, S. Maouche, J. S. Moore, D. Muir, Ganesh Sk, E. Murray, Patrick Segers, Ramachandran S. Vasan, Fernando Rivadeneira, J. Neudert, Xiuqing Guo, D. Niblett, Thomas J. Wang, K. O'leary, Mattace Raso Fu, Brigitte Kühnel, W. H. Ouwehand, Larson Mg, H. Pollard, Jouke-Jan Hottenga, A. Rankin, Sijbrands Ej, C. M. Rice, Mladen Boban, Daniel I. Chasman, H. Sager, Uitterlinden Ag, Peter Vollenweider, J. Sambrook, G. Schmitz, Hwang Sj, Jennifer L. Bragg-Gresham, M. Scholz, Gerard Waeber, L. Schroeder, Behrooz Z. Alizadeh, Vasan Rs, H. Schunkert, Verwoert Gc, John C. Chambers, Albert Hofman, Xinzhong Li, Wang Tj, Anneli Pouta, Eco Jc C. de Geus, Paavo Zitting, Reilly, Suman Kundu, Kent D. Taylor, R. McPherson, M. Li, K. Musunuru, Johnson Ad, Uwe Völker, A. Schillert, M. M. Van Der Klauw, R. Roberts, Henry Völzke, Melanie Mm van der Klauw, McArdle Wl, LifeLines Cohort Study, R. Myers, Mari-Liis Tammesoo, T. Quertermous, Kroemer Hk, N. Risch, R. Schnabel, Santhi K. Ganesh, Nicaud, H. J. Rupprecht, Sven Bergmann, C. Perret, Glazer Nl, C. Proust, T. Münzel, Taylor Kd, T. Lumley, K. Marciante, Harris Tb, Jaana Laitinen, C. J. O' Donnell, K. Rice, J. I. Rotter, Shih-Jen Hwang, Ramachandran, Rice Km, W. Lieb, S. Schreiber, Tammesoo Ml, Ilja M. Nolte, K. W. Van Dijk, Gary F. Mitchell, Mark Lathrop, C. Loley, Brenda W. Penninx, A. Medack, C. Meisinger, J. Nahrstedt, Elin Org, Khaw Kt, Siim Sõber, A. Peters, Helene Alavere, Xiaowen Lu, Benjamin F. Voight, Toomas Haller, W. März, A. Meinitzer, Aime Keis, S. Pilz, Heyo K. Kroemer, W. Renner, H. Scharnagl, L. Peltonen, C. M. Van Duijn, Yurii Aulchenko, S. M. Schwartz, L. Qu, Corrado Masciullo, Nicole L. Glazer, Inês S. Barroso, Nolte Im, W. Matthai, A. D. Pichard, Tamara B. Harris, Cinzia Sala, Penninx Bw, Smith Av, Pilar Galan, L. Satler, J. M. Lindsay, D. J. Rader, Serge Hercberg, Olle Melander, L. R. Loehr, W. D. Rosamond, Ehret Gb, Veikko Salomaa, Susana Eyheramendy, J. Murabito, C. Pattaro, M. Olden, Voight Bf, O'connell, G. Paré, K. Lohman, Kay-Tee Khaw, Sheila Ulivi, O'Donnell Cj, N. M. Probst-Hensch, E. Rampersaud, Aw William Musk, B. D. Mitchell, J. Metter, So-Youn Shin, Tanguy Corre, M. Province, R. B. Schnabel, T. F. Munzel, Leif Groop, T. S. Leak, C. Minelli, D. Nitsch, R. Mägi, Collins Fs, M. Nauck, Ko Willems van Dijk

, Massimo Mangino, T. Rochat, van der Klauw Mm, Bergman Rn, B. Paulweber, I. Prokopenko, Nicole Soranzo, Antonella Fabretto, Beilby Jp, P. P. Pramstaller

, L. Lind, Flavio Faletra, Hugh Watkins, Samer Ss Najjar, R. J. Rodeheffer, Musk Aw, The LifeLines Cohort Study, T. Reffelmann, M. M. Redfield, Maurizio Facheris, G. M. Lord, Shin Sy, Marisa Loitfelder, Marion Zeginigg, D. A. Lawlor, Bis Jc, J. S. Sehmi, Cornelia M. van Duijn, Y. Li, K. Luttropp, C. Maréchal, Fabiola M. Del Greco, Joseph Hung, Alex N. Parker, L. Nordfors, E. Perucha, Francis S. Collins, P. J. Roderick, Pau Navarro, A. Ruokonen, Lynda M. Rose, M. Schalling, Richard N. Bergman, D. Schlessinger, G. Schlieper, John P. Beilby, Andrew Singleton, Seelen, P. H. Maxwell, M. I. McCarthy, L. Lightstone, Anuj Goel, G. Navis, Gonneke Willemsen, Najjar Ss, Anders Hamsten, Janssens Ac, Wild Sh, Corsi Am, Pierre Gider, Marcus Doerr, A. Cecile J. W. Janssens, David J. Stott, Dena Hernandez, Jouke-Jan Hotteng, de Geus Ej, Brigitte Kuehnel, Marco Orru, Manuela Uda, Parker An, Y. D. Chen, M. Fabiola Del Greco, Rose Lm, M. Fabiola Del Greco, Weihua Zhang, Cockcroft, G. Eiriksdottir, John M. Starr, E. J. Benjamin, James Scott, Anna Maria Corsi, N. M. Hamburg

, A. Isaacs, D. M. Herrington, J. S. Andrews, J. Ding, T. D. Howard, Q. Gibson, Brendan Buckley, A. Dehghan, E. G. Lakatta, Jorma Viikari, Jan H. Lindeman, E. Jewell, Chen Yd, T. Attwood, S. Belz, Burke Gl, Yii-Der Ida Chen, Thomas Meitinger, P. Braund, F. Cambien, J. Cooper, Adamo Pio D'adamo

, A. Crisp-Hihn, P. Deloukas, N. Foad, J. Eardman, A. H. Goodall, Andrew Plump, J. Gracey, E. Gray, Starr Jm, S. Gulde, R. Gwilliams, Mika Kähönen, S. Heimerl, Dirk De Bacquer

, C. Hengstenberg, Lindeman Jh, J. Jolley, Angela Döring, Gregory L. Burke, U. Krishnan, Hoen Pa, Nilesh J. Samani, Gui G. De Backer, Halit Ongen, Marc L. De Buyzere, König Ir, Gail Davies, EchoGen Consortium, Sofie Bekaert, He-Erich Wichmann, Valur Emilsson, Thierry C. Gillebert, Felix Jf, Tim De Meyer, S. Kathiresan, Hopewell Jc, T. L. Assimes, A. Hall, Olli T. Raitakari, R. Laaksonen, D. Absher, Kari Stefansson, L. Chen, Ir R. König, Ronald P. Stolk, L. A. Cupples, Gudmar Thorleifsson, E. Halperin, Unnur Thorsteinsdottir, Destefano Al, Robert Clarke, Alan F. Wright, T. L. Assime, Y.-D. I. Chen, E. J. C. De Geus, S. Fortmann, AortaGen Consortium, Janine F. Felix, A. Go, M. Hlatky, C. Iribarren, Monique Breteler, Mitchell Gf, James F. Wilson, Michael Preuss

, J. Knowles, Jemma C. Hopewell, Al L. Destefano, Stéphanie Debette, Igor Rudan, S. Blankenberg, Smith Nl, K. Lackner, Tim D. Spector, KidneyGen Consortium, C. Bickel, Myriam Fornage, M. Barbalic, I. Y. Chen, L. Cupples, Lyle J. Palmer, Walter Palmas, S. Demissie-Banjaw, A. Folsom, S. Heckbert, Hilma Holm, Peter A. C. 'T T. Hoen, CKDGen Consortium, Cardiogenics Consortium, Inke R. König, S. Gretarsdottir, Gulcher, A. Kong, K. Andersen, Ruth Jf F. Loos, Samani Nj, M. Fischer, A. Grosshennig, Anita L. DeStefano, Z. Aherrahrou, The CKDGen Consortium, P. Bruse, Angela Doering, T. Illig, N. Klopp, Nicholas J. Wareham, B. O. Böhm, Caroline Hayward, Reinhold Schmidt, H. Dobnig, Deary Ij, Ian J. Deary, T. B. Grammer, M. M. Hoffmann, Ulf B. Gyllensten, Wichmann He, Ben A. Oostra, M. Kleber, The Cardiogenics Consortium, Peter Ac C. 't Hoen, Raitakari Ot, C. Guiducci, Jaakko Tuomilehto, N. Burtt, David P. Strachan, S. B. Gabriel, R. Elosua, Jaspal S. Kooner, Arne Pfeufer, Kooner Js, S. Dandona, Jacqueline Cm M. Witteman, O. Jarinova, David Siscovick, Stolk Rp, Jw Wouter Jukema, Marcus Dörr, Jukema Jw, H. H. Hakonarson, J. Devaney, Wright Af, Dorret I. Boomsma, Burnett, Daniela Toniolo, K. M. Kent, Boomsma Di, Stefania Bandinelli, C. W. Knouff, Harold Snieder, Mika Kahonen, S. E. Epstein, Paul M. Ridker, P. S. Braund, A. J. Balmforth, Gyllensten Ub, S. G. Ball, A. S. Hall, Pierre Meneton, Luigi Ferrucci, Wilson Jf, S. Demissie, Yurii S. Aulchenko, A. R. Folsom, E. Benjamin, Martin Farrall, T. Haritunians, D. Couper, J. S. Gottdiener, P. P. Chang, Heckbert, Andres Metspalu, Spector Td, E. R. Fox, Consortium Heart Failure Working Group Charge, Lenore Launer, A. Köttgen, Patricia B. Munroe, Inke R. Koenig, Palmer Lj, Rainer Rettig, C. A. Böger, Bruce M. Psaty, C. Fuchsberger, Martin D. Tobin, X. Gao, Paolo Gasparini, Peter A. C 't Hoen, S. Ketkar, Jacques S. Beckmann, E. J. Atkinson, M. C. Cornelis, Dabeeru C. Rao, F. Kronenberg, David Altshuler, D. E. Arking, M. Cavalieri, W. Koenig, F. Giallauria, M. Feitosa, Loos Rj, I. Kolcic, The CardioGram, F. B. Hu, A. Johansson, Christian Gieger

, D. Ellinghaus, M. Imboden, A. Brandstätter, B. Kollerits, L. Kedenko, P. Kovacs, S. Campbell, K. Endlich, S. Badola, Wareham Nj, H. Erich Wichmann, S. L. Kardia, Oostra Ba, G. C. Curhan, A. Franke, J. Coresh, I. Borecki, B. K. Krämer, N. Hastie, Christopher Newton-Cheh, W. H. Kao, I. M. Heid, C. S. Fox, S. B. Felix, Daniel Levy, Strachan Dp, G. Homuth, J. Aragam, Beckmann Js, K. H. Greiser, Jeanette Erdmann, J. W. Deckers, Witteman Jc, K. J. Lackner, E. Ingelsson, Eric Boerwinkle, I. Kullo, J. Haerting, D. K. Arnett, The EchoGen Consortium, Michael Boehnke, Marjo-Riitta Jarvelin, M. Blettner, N. Friedrich, D. P. Gale, The AortaGen Consortium, Ridker Pm, K. R. Ahmadi, Gonçalo R. Abecasis, S. J. Bakker, Aravinda Chakravarti, van Dijk Kw, H. J. Bilo, Jarvelin Mr, M. J. Brown, J. M. Connell, H. T. Cook, I. Cotlarciuc, Vilmundur Gudnason, G. Davey Smith, G. Deng, Abecasis Gr, O. Devuyst, L. D. Dikkeschei, N. Dimkovic, M. Dockrell, A. Dominiczak, S. Ebrahim, T. Eggermann, J. Floege, Mark J. Caulfield, Munroe Pb, N. G. Forouhi, R. T. Gansevoort, Psaty Bm, X. Han, B. Hedblad, J. J. Homan van der Heide, Caulfield Mj, B. G. Hepkema, M. Hernandez-Fuentes, E. Hypponen, Rao Dc, N. Kleefstra, Paul Elliott, Lagou, M. Lapsley, Tobin Md, The Charge Consortium Heart Failure, The KidneyGen Consortium, , van Duijn Cm

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Abstract

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.

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Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Abstract