Genome-wide association studies of breast cancer have identified multiple single nucleotide polymorphisms (SNPs) that are associated with increased breast cancer risks in the general population. In a previous study, we demonstrated that the minor alleles at three of these SNPs, in FGFR2, TNRC9 and MAP3K1, also confer increased risks of breast cancer for BRCA1 or BRCA2 mutation carriers. Three additional SNPs rs3817198 at LSP1, rs13387042 at 2q35 and rs13281615 at 8q24 have since been reported to be associated with breast cancer in the general population, and in this study we evaluated their association with breast cancer risk in 9442 BRCA1 and 5665 BRCA2 mutation carriers from 33 study centres. The minor allele of rs3817198 was associated with increased breast cancer risk only for BRCA2 mutation carriers [hazard ratio (HR) = 1.16, 95% CI: 1.07–1.25, P-trend = 2.8 x 10–4]. The best fit for the association of SNP rs13387042 at 2q35 with breast cancer risk was a dominant model for both BRCA1 and BRCA2 mutation carriers (BRCA1: HR = 1.14, 95% CI: 1.04–1.25, P = 0.0047; BRCA2: HR = 1.18 95% CI: 1.04–1.33, P = 0.0079). SNP rs13281615 at 8q24 was not associated with breast cancer for either BRCA1 or BRCA2 mutation carriers, but the estimated association for BRCA2 mutation carriers (per-allele HR = 1.06, 95% CI: 0.98–1.14) was consistent with odds ratio estimates derived from population-based case–control studies. The LSP1 and 2q35 SNPs appear to interact multiplicatively on breast cancer risk for BRCA2 mutation carriers. There was no evidence that the associations vary by mutation type depending on whether the mutated protein is predicted to be stable or not. Antonis C. Antoniou1,*, Olga M. Sinilnikova2, Lesley McGuffog1, Sue Healey3, Heli Nevanlinna4, Tuomas Heikkinen4, Jacques Simard5, Amanda B. Spurdle3, Jonathan Beesley3, Xiaoqing Chen3, The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer6, Susan L. Neuhausen7, Yuan C. Ding7, Fergus J. Couch8, Xianshu Wang8, Zachary Fredericksen8, Paolo Peterlongo9,10, Bernard Peissel9, Bernardo Bonanni11, Alessandra Viel12, Loris Bernard11,13, Paolo Radice9,10, Csilla I. Szabo14, Lenka Foretova15, Michal Zikan16, Kathleen Claes17, Mark H. Greene18, Phuong L. Mai18, Gad Rennert19, Flavio Lejbkowicz19, Irene L. Andrulis20,21,22, Hilmi Ozcelik21, Gord Glendon20, OCGN20, Anne-Marie Gerdes23, Mads Thomassen23, Lone Sunde24, Maria A. Caligo25, Yael Laitman26, Tair Kontorovich26, Shimrit Cohen26, Bella Kaufman27,28, Efrat Dagan29, Ruth Gershoni Baruch29, Eitan Friedman26,28, Katja Harbst30, Gisela Barbany-Bustinza31, Johanna Rantala31, Hans Ehrencrona32, Per Karlsson33, Susan M. Domchek34, Katherine L. Nathanson34, Ana Osorio35, Ignacio Blanco36, Adriana Lasa37, Javier Benítez35, Ute Hamann38, Frans B.L. Hogervorst39, Matti A. Rookus40, J. Margriet Collee41, Peter Devilee42, Marjolijn J. Ligtenberg44, Rob B. van der Luijt45, Cora M. Aalfs46, Quinten Waisfisz47, Juul Wijnen43, Cornelis E.P. van Roozendaal48, HEBON49, Susan Peock1, Margaret Cook1, Debra Frost1, Clare Oliver1, Radka Platte1, D. Gareth Evans50, Fiona Lalloo50, Rosalind Eeles51, Louise Izatt52, Rosemarie Davidson53, Carol Chu54, Diana Eccles55, Trevor Cole56, Shirley Hodgson57, EMBRACE1, Andrew K. Godwin58, Dominique Stoppa-Lyonnet59, Bruno Buecher60, Mélanie Léoné2, Brigitte Bressac-de Paillerets61,62, Audrey Remenieras61, Olivier Caron63, Gilbert M. Lenoir61,64, Nicolas Sevenet65, Michel Longy65,66, Sandra Fert Ferrer67, Fabienne Prieur68, GEMO2,59, David Goldgar69, Alexander Miron70, Esther M. John71, Saundra S. Buys72, Mary B. Daly58, John L. Hopper73, Mary Beth Terry74, Yosuf Yassin70, Breast Cancer Family Registry, Christian Singer75, Daphne Gschwantler-Kaulich75, Christine Staudigl75, Thomas v. O. Hansen76, Rosa Bjork Barkardottir77, Tomas Kirchhoff78, Prodipto Pal78, Kristi Kosarin78, Kenneth Offit78, Marion Piedmonte79, Gustavo C. Rodriguez80, Katie Wakeley81, John F. Boggess82, Jack Basil83, Peter E. Schwartz84, Stephanie V. Blank85, Amanda E. Toland86,87, Marco Montagna88, Cinzia Casella88, Evgeny N. Imyanitov89, Anna Allavena90, Rita K. Schmutzler91, Beatrix Versmold91, Christoph Engel92, Alfons Meindl93, Nina Ditsch94, Norbert Arnold96, Dieter Niederacher96, Helmut Deißler97, Britta Fiebig98, Christian Suttner99, Ines Schönbuchner100, Dorothea Gadzicki101, Trinidad Caldes102, Miguel de la Hoya102, Karen A. Pooley1, Douglas F. Easton1, Georgia Chenevix-Trench3 on behalf of CIMBA.