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Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
Journal article published in 2008 by
Consortium Year,
Anne Barton 
,
Wendy Thomson,
Xiayi Ke,
Steve Eyre ,
Anne Hinks,
John Bowes,
Darren Plant,
Laura J. Gibbons,
Anthony G. Wilson,
Deborah E. Bax,
Wellcome Trust Case Control Consortium,
Ann W. Morgan,
Paul Emery,
Gibbons Lj
and other authors.
,
Wendy Thomson,
Xiayi Ke,
Steve Eyre ,
Anne Hinks,
John Bowes,
Darren Plant,
Laura J. Gibbons,
Anthony G. Wilson,
Deborah E. Bax,
Wellcome Trust Case Control Consortium,
Ann W. Morgan,
Paul Emery,
Gibbons Lj
and other authors.
Abstract
The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.