Published in

Nature Research, Nature Genetics, 8(41), p. 879-881, 2009

DOI: 10.1038/ng.416

Links

Tools

Export citation

Search in Google Scholar

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

Journal article published in 2009 by Emelia J. Benjamin, Kenneth M. Rice, Dan E. Arking, Arne Pfeufer, Charlotte van Noord, Ralph B. D'Agostino, Ralph B. D’Agostino, Albert V. Smith ORCID, Renate B. Schnabel, Joshua C. Bis, Eric Boerwinkle, Moritz F. Sinner, Abbas Dehghan ORCID, Steven A. Lubitz, Thomas Lumley and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10−7), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10−11). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10−15).