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Nature Research, Nature Communications, 1(6), 2015

DOI: 10.1038/ncomms6751

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A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Journal article published in 2015 by Joseph Vijai, Zhaoming Wang, Sonja I. Berndt, Christine F. Skibola, Susan L. Slager, Silvia de Sanjose, Mads Melbye, Bengt Glimelius, Paige M. Bracci, Lucia Conde, Brenda M. Birmann, Sophia S. Wang, Angela R. Brooks-Wilson, Qing Lan, Paul I. W. de Bakker and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractMarginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10−15) and HLA-B (rs2922994, P=2.43 × 10−9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.