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Wiley, Developmental Dynamics, 12(236), p. 3343-3357, 2007

DOI: 10.1002/dvdy.21335

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Caenorhabditis elegans germ line: A model for stem cell biology

Journal article published in 2007 by E. Jane Albert Hubbard ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Like many stem cell systems, the Caenorhabditis elegans germ line contains a self-renewing germ cell population that is maintained by a niche. Although the exact cellular mechanism for self-renewal is not yet known, three recent studies shed considerable light on the cell cycle behavior of germ cells, including a support for significant and plastic renewal potential. This review brings together the results of the three recent cell-based studies, places them in the context of previous work, and discusses future perspectives for the field.