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Springer Nature [academic journals on nature.com], International Journal of Obesity, 12(23), p. 1307-1313, 1999

DOI: 10.1038/sj.ijo.0801072

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Effect of obesity and insulin resistance on resting and glucose-induced thermogenesis in man

Journal article published in 1999 by S. Camastra ORCID, E. Bonora, S. Del Prato, K. Rett, M. Weck, E. Ferrannini, Ferrannini E. On Behalf Of Egir
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

OBJECTIVE: to assess the impact of obesity and insulin sensitivity on resting (REE) and glucose-induced thermogenesis (GIT). DESIGN: Data from 322 studies carried out in non-diabetic subjects of either gender, covering a wide range of age (18 ± 80 y) and body mass index (BMI, 18 ± 50 kg=m2). MEASUREMENTS: Insulin sensitivity and thermogenesis were measured by combining the euglycaemic insulin clamp technique with indirect calorimetry. RESULTS: REE was inversely related to age (P 0.001) and the respiratory quotient (P 0.03), and positively related to BMI, lean body mass (LBM), fat mass, and percentage fat mass (all p