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BMJ Publishing Group, Archives of Disease in Childhood, 3(75), p. 245-246, 1996

DOI: 10.1136/adc.75.3.245

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Familial hypothyroidism with autosomal dominant inheritance.

Journal article published in 1996 by M. Mimouni, A. Mimouni-Bloch ORCID, J. Schachter, M. Shohat
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This paper is available in a repository.

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Abstract

Three generations of a family with clinical and subclinical hypothyroidism caused by thyroid stimulating hormone (TSH) unresponsiveness are described. Findings were low to normal serum thyroxine, raised serum TSH, and low radioiodine uptake; goitre was notably absent. This family is the first evidence of an autosomal dominant mode of transmission of TSH unresponsiveness and may enable identification of the precise defect by genetic linkage study.