Published in
Elsevier, Tetrahedron, 50(65), p. 10424-10429, 2009
DOI: 10.1016/j.tet.2009.10.026
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Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei
Journal article published in 2009 by
Carmen Festa 
,
Simona De Marino ,
Valentina Sepe,
Maria Chiara Monti,
Paolo Luciano,
Maria Valeria D'Auria,
Cécile Debitus,
Mariarosaria Bucci,
Valentina Vellecco,
Angela Zampella
,
Simona De Marino ,
Valentina Sepe,
Maria Chiara Monti,
Paolo Luciano,
Maria Valeria D'Auria,
Cécile Debitus,
Mariarosaria Bucci,
Valentina Vellecco,
Angela Zampella
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Abstract
Two new metabolites, perthamides C and D, have been isolated from the marine sponge Theonella swinhoei. Their structures were determined by interpretation of NMR and ESIMS data. All compounds exhibited in vivo potent anti-inflammatory activity. Biological activity and structural elucidation are reported.