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Nature Research, Nature Genetics, 6(41), p. 645-647, 2009

DOI: 10.1038/ng.387

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Loci at chromosomes 13, 19 and 20 influence age at natural menopause

Journal article published in 2009 by Lisette Stolk, Guangju Zhai, Joyce B. J. van Meurs ORCID, Michael M. P. J. Verbiest, J. B. van Meurs, Jenny A. Visser, Karol Estrada, Fernando Rivadeneira, Frances M. Williams, Lynn Cherkas, Panos Deloukas ORCID, Nicole Soranzo, Jules J. de Keyzer, J. J. Keyzer, Victor J. M. Pop and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 × 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.